Prado Carolina, Herrada Andrés A, Hevia Daniel, Goiry Lorna Galleguillos, Escobedo Noelia
Laboratorio de Neuroinmunología, Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Santiago, Chile.
Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.
Front Immunol. 2025 Feb 17;16:1540263. doi: 10.3389/fimmu.2025.1540263. eCollection 2025.
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory and neurodegenerative disease affecting the central nervous system (CNS). MS is associated with a complex interplay between neurodegenerative and inflammatory processes, mostly attributed to pathogenic T and B cells. However, a growing body of preclinical and clinical evidence indicates that innate immunity plays a crucial role in MS promotion and progression. Accordingly, preclinical and clinical studies targeting different innate immune cells to control MS are currently under study, highlighting the importance of innate immunity in this pathology. Here, we reviewed recent findings regarding the role played by innate immune cells in the pathogenesis of MS. Additionally, we discuss potential new treatments for MS based on targets against innate immune components.
多发性硬化症（MS）是一种影响中枢神经系统（CNS）的慢性自身免疫性、炎症性和神经退行性疾病。MS与神经退行性和炎症过程之间的复杂相互作用有关，这主要归因于致病性T细胞和B细胞。然而，越来越多的临床前和临床证据表明，先天免疫在MS的发生和发展中起着关键作用。因此，目前正在进行针对不同先天免疫细胞以控制MS的临床前和临床研究，这突出了先天免疫在这种病理中的重要性。在此，我们综述了关于先天免疫细胞在MS发病机制中作用的最新研究结果。此外，我们还讨论了基于针对先天免疫成分的靶点的MS潜在新疗法。
