Gumber Sanjeev, Courtney Cynthia L, Strait Karen R, Sharma Prachi, Freebersyser Julie E, Crane Maria M
Division of Pathology, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA.
Exp Toxicol Pathol. 2013 Nov;65(7-8):1121-5. doi: 10.1016/j.etp.2013.05.003. Epub 2013 Jun 2.
Retrograde ejaculation (RE) has been reported in humans and animals but RE with subsequent sperm calculi has rarely been reported. This report documents clinical and pathological findings of spontaneous sperm cystolithiasis in four rhesus macaques. While this condition has been associated with repeated electroejaculation, spontaneous sperm cystolithiasis is highly unusual. The animals presented with either stranguria, dysuria, hematuria, distended abdomen or lethargy. Ultrasound examination revealed several hyperechoic masses within the lumen of the urinary bladder. The animals were euthanized due to poor prognosis or study end points. Postmortem examination revealed multiple angular, amorphous, soft to firm, pale yellow to greenish-brown and variably sized calculi in the lumen of the urinary bladder or prostatic/penile urethra. Histologically, the calculi were composed of numerous sperm embedded in abundant brightly eosinophilic matrix. Based on gross and histologic findings, RE associated sperm cystolithiasis was diagnosed, with ulcerative urethritis as the major primary apparent etiology. To the authors' knowledge, this is the first report of four spontaneous cases of sperm cystolithiasis in rhesus macaques.
逆行射精（RE）在人类和动物中均有报道，但随后并发精子结石的逆行射精却鲜有报道。本报告记录了4只恒河猴自发性精子囊肿结石症的临床和病理表现。虽然这种情况与反复电射精有关，但自发性精子囊肿结石症非常罕见。这些动物表现为排尿困难、尿痛、血尿、腹部膨胀或嗜睡。超声检查显示膀胱腔内有多个高回声团块。由于预后不良或研究终点，这些动物被实施安乐死。尸检发现膀胱腔或前列腺/阴茎尿道内有多个呈角状、无定形、质地由软到硬、颜色从淡黄色到绿褐色且大小不一的结石。组织学检查显示，结石由大量嵌入丰富的嗜酸性基质中的精子组成。根据大体和组织学检查结果，诊断为与逆行射精相关的精子囊肿结石症，主要原发性明显病因是溃疡性尿道炎。据作者所知，这是首次报道4例恒河猴自发性精子囊肿结石症病例。
