Belluco S, Brisebard E, Watrelot D, Pillet E, Marchal T, Ponce F
Service d'Anatomie Pathologique, VetAgro Sup, Campus Vétérinaire, 1, avenue Bourgelat, 69280 Marcy l'etoile, France. Email:
Vet Pathol. 2013 Nov;50(6):1078-82. doi: 10.1177/0300985813490757. Epub 2013 Jun 4.
Squamous cell carcinoma represents 47.4% of all malignant canine digital lesions, but despite its frequency, there are few published studies available. Pathology submission records of 154 cases and follow-up of 49 animals were analyzed. On the 49 cases, histological evaluation was performed of the differentiation degree, mitotic index, presence of emboli, and immunohistochemical expression of vimentin and E-cadherin. The mean (SD) age of affected animals was 10.2 (2.3) years; no sex predisposition was recorded. Beauceron and Briard were 2 new overrepresented breeds. Dark-haired animals comprised 97 of 105 (92%); 94 dogs of 125 (75.2%) belonged to large and giant breeds. The forelimb was affected twice more than the hind limb. Probable metastases were observed in 4 dogs; new tumor development was recorded in 11 of 49 (22.4%). Epidemiologic factors, histological grade, mitotic index, and expression of immunohistochemical markers seemed not to be related to the clinical outcome.
鳞状细胞癌占所有犬类恶性趾部病变的47.4%，但尽管其发病率较高，却鲜有已发表的研究。分析了154例病例的病理送检记录以及49只动物的随访情况。对这49例病例进行了组织学评估，包括分化程度、有丝分裂指数、栓子的存在情况以及波形蛋白和E-钙黏蛋白的免疫组化表达。患病动物的平均（标准差）年龄为10.2（2.3）岁；未记录到性别倾向。博瑞犬和布里犬是2种新出现的高发品种。105只中有97只（92%）为深色毛发动物；125只中有94只（75.2%）属于大型和巨型犬种。前肢受累的几率是后肢的两倍。4只犬观察到可能发生转移；49只中有11只（22.4%）记录到有新肿瘤形成。流行病学因素、组织学分级、有丝分裂指数以及免疫组化标志物的表达似乎与临床结果无关。
