Am J Gastroenterol. 2013 Jun;108(6):923-5. doi: 10.1038/ajg.2013.83.
Thrift et al. provide preliminary evidence that younger age of symptomatic gastroesophageal reflux disease exposure is associated with increased risk of Barrett's esophagus. If these findings are confirmed in other studies, the next logical steps are to test whether this, and other age-specific exposures, can help optimize predictive models of Barrett's esophagus and progression to esophageal adenocarcinoma. Expansion of these models to the general population and the greater Barrett's esophagus population, respectively, will be required for a screening and surveillance approach to be clinically successful and cost-effective.
Thrift 等人提供了初步证据，表明症状性胃食管反流病暴露的年龄越小，患巴雷特食管的风险就越高。如果这些发现在其他研究中得到证实，那么下一步就是测试这种情况以及其他特定年龄段的暴露是否有助于优化巴雷特食管和食管腺癌进展的预测模型。为了使筛查和监测方法在临床上取得成功并具有成本效益，需要将这些模型分别扩展到一般人群和更大的巴雷特食管人群。
