Department of Pharmacology & Therapeutics, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland.
Heart. 2013 Aug;99(16):1179-84. doi: 10.1136/heartjnl-2013-303921. Epub 2013 Jun 4.
To examine age and gender specific trends in coronary heart disease (CHD) and stroke mortality in two neighbouring countries, the Republic of Ireland (ROI) and Northern Ireland (NI).
Epidemiological study of time trends in CHD and stroke mortality.
SETTING/PATIENTS: The populations of the ROI and NI, 1985-2010.
None.
Directly age standardised CHD and stroke mortality rates were calculated and analysed using joinpoint regression to identify years where the slope of the linear trend changed significantly. This was performed separately for specific age groups (25-54, 55-64, 65-74 and 75-84 years) and by gender. Annual percentage change (APC) and 95% CIs are presented.
There was a striking similarity between the two countries, with percentage change between 1985 and 1989 and between 2006 and 2010 of 67% and 69% in CHD mortality, and 64% and 62% in stroke mortality for the ROI and NI, respectively. However, joinpoint analysis identified differences in the pace of change between the two countries. There was an accelerated pace of decline (negative APC) in mortality for both CHD and stroke in both countries from the mid-1990s (APC ROI -8% (95% CI -9.5 to 6.5) and NI -6.6% (-6.9 to -6.3)), but the accelerated decrease started later for CHD mortality in the ROI. In recent years, a levelling off in CHD mortality was observed in the 25-54 year age group in NI and in stroke mortality for men and women in the ROI.
While differences in the pace of change in mortality were observed at different time points, similar, substantial decreases in CHD and stroke mortality were achieved between 1985 and 1989 and between 2006 and 2010 in the ROI and NI despite important differences in health service structures. There is evidence of a levelling in mortality rates in some groups in recent years.
研究两个邻国爱尔兰共和国(ROI)和北爱尔兰(NI)冠心病(CHD)和中风死亡率的年龄和性别特定趋势。
CHD 和中风死亡率时间趋势的流行病学研究。
地点/患者:ROI 和 NI 的人群,1985-2010 年。
无。
直接年龄标准化 CHD 和中风死亡率,并使用连接点回归分析来确定线性趋势斜率明显变化的年份。这是针对特定年龄组(25-54、55-64、65-74 和 75-84 岁)和性别分别进行的。呈现了年百分比变化(APC)和 95%置信区间。
两个国家之间存在惊人的相似之处,CHD 死亡率的百分比变化分别为 1985 年至 1989 年和 2006 年至 2010 年的 67%和 69%,以及中风死亡率的 64%和 62%,ROI 和 NI 分别。然而,连接点分析确定了两国之间变化速度的差异。自 20 世纪 90 年代中期以来,CHD 和中风的死亡率均呈加速下降趋势(负 APC)(ROI 的 APC 为-8%(95%CI -9.5 至 6.5)和 NI 的-6.6%(-6.9 至-6.3)),但 ROI 中的 CHD 死亡率下降速度较晚。近年来,NI 中 25-54 岁年龄组的 CHD 死亡率和 ROI 中男性和女性的中风死亡率趋于平稳。
尽管在不同的时间点观察到死亡率变化速度的差异,但尽管在卫生服务结构方面存在重要差异,但在 ROI 和 NI 中,1985 年至 1989 年和 2006 年至 2010 年之间,CHD 和中风死亡率均实现了类似的、实质性的下降。近年来,一些群体的死亡率趋于平稳。