含宏结构域蛋白：调节单（ADP-核糖基）化的新细胞内功能。
Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation.
机构信息
Institute of Biochemistry and Molecular Biology, Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
出版信息
Nat Rev Mol Cell Biol. 2013 Jul;14(7):443-51. doi: 10.1038/nrm3601. Epub 2013 Jun 5.
ADP-ribosylation of proteins was first described in the early 1960's, and today the function and regulation of poly(ADP-ribosyl)ation (PARylation) is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl)ation (MARylation) by ADP-ribosyl transferase (ART) enzymes, such as ARTD10. Recent findings indicate that MARylation regulates signalling and transcription by modifying key components in these processes. Emerging evidence also suggests that specific macrodomain-containing proteins, including ARTD8, macroD1, macroD2 and C6orf130, which are distinct from those affecting PARylation, interact with MARylation on target proteins to 'read' and 'erase' this modification. Thus, studying macrodomain-containing proteins is key to understanding the function and regulation of MARylation.
蛋白质的 ADP-核糖基化最早在 20 世纪 60 年代被描述，而如今聚（ADP-核糖基）化（PARylation）的功能和调控已被部分阐明。相比之下，ADP-核糖基转移酶（ART）酶介导的细胞内单（ADP-核糖基）化（MARylation），如 ARTD10，其相关信息知之甚少。最近的研究结果表明，MARylation 通过修饰这些过程中的关键成分来调节信号转导和转录。新出现的证据还表明，特定的Macrodomain 蛋白，包括 ARTD8、macroD1、macroD2 和 C6orf130，它们与影响 PARylation 的蛋白不同，与靶蛋白上的 MARylation 相互作用，从而“读取”和“擦除”这种修饰。因此，研究包含 Macrodomain 的蛋白是理解 MARylation 的功能和调控的关键。
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