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迷走神经刺激对运动阈值的促进作用:对其抗抑郁作用机制的影响?

Facilitative effects of VNS on the motor threshold: implications for its antidepressive mode of action?

机构信息

Department of Psychiatry and Psychotherapy, University Hospital of Friedrich Alexander University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany,

出版信息

J Neural Transm (Vienna). 2013 Oct;120(10):1507-10. doi: 10.1007/s00702-013-1043-8. Epub 2013 Jun 5.

DOI:10.1007/s00702-013-1043-8
PMID:23736944
Abstract

In the present study, the effects of vagus nerve stimulation (VNS) on the resting motor threshold (rMT) of patients treated with repetitive transcranial magnetic stimulation were evaluated. Patients showed a significant decrease in the rMT during VNS-on stimulation. VNS was the only significant factor affecting rMT changes and did not appear to be a static variable. Further studies should focus on the effect of VNS on neural neurogenesis in depressive disorders, and the effects of other treatment options for major depressive disorder on the rMT should also be determined.

摘要

在本研究中,评估了迷走神经刺激(VNS)对接受重复经颅磁刺激治疗的患者静息运动阈值(rMT)的影响。患者在 VNS 开启刺激时表现出 rMT 的显著降低。VNS 是唯一显著影响 rMT 变化的因素,且似乎不是一个静态变量。进一步的研究应集中在 VNS 对抑郁障碍中神经发生的影响上,还应确定其他治疗选择对 rMT 的影响。

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Front Neurosci. 2018 Apr 10;12:239. doi: 10.3389/fnins.2018.00239. eCollection 2018.

本文引用的文献

1
Resting motor threshold changes in vagus nerve stimulation-treated patients during on/off-stimulation conditions.
Psychiatry Clin Neurosci. 2013 Jan;67(1):64-5. doi: 10.1111/pcn.12000.
2
Transcranial direct current stimulation modulates motor responses evoked by repetitive transcranial magnetic stimulation.经颅直流电刺激调节重复经颅磁刺激诱发的运动反应。
Neurosci Lett. 2012 Aug 1;522(2):167-71. doi: 10.1016/j.neulet.2012.06.033. Epub 2012 Jun 23.
3
The role of transcranial magnetic stimulation in treatment-resistant depression: a review.经颅磁刺激在治疗抵抗性抑郁症中的作用:综述。
Curr Pharm Des. 2012;18(36):5846-52. doi: 10.2174/138161212803523644.
4
The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy.难治性和超难治性惊厥性癫痫持续状态治疗的结果和治疗建议。
Brain. 2012 Aug;135(Pt 8):2314-28. doi: 10.1093/brain/aws091. Epub 2012 May 9.
5
Vagus nerve stimulation ameliorated deficits in one-way active avoidance learning and stimulated hippocampal neurogenesis in bulbectomized rats.迷走神经刺激改善了海人酸损毁大鼠在一次性被动回避学习中的缺陷,并刺激了海马神经发生。
Brain Stimul. 2013 Jan;6(1):78-83. doi: 10.1016/j.brs.2012.01.009. Epub 2012 Feb 24.
6
Applications of transcranial magnetic stimulation (TMS) in child and adolescent psychiatry.经颅磁刺激(TMS)在儿童和青少年精神病学中的应用。
Int Rev Psychiatry. 2011 Oct;23(5):445-53. doi: 10.3109/09540261.2011.623688.
7
Novel attempts to optimize vagus nerve stimulation parameters on serotonin neuronal firing activity in the rat brain.新型尝试优化大鼠脑内血清素神经元放电活动的迷走神经刺激参数。
Brain Stimul. 2012 Jul;5(3):422-429. doi: 10.1016/j.brs.2011.04.005. Epub 2011 May 11.
8
Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats.5-羟色胺能和去甲肾上腺素能通路是重复迷走神经刺激在大鼠中产生抗焦虑和抗抑郁样行为效应所必需的。
Biol Psychiatry. 2011 Nov 15;70(10):937-45. doi: 10.1016/j.biopsych.2011.07.020. Epub 2011 Sep 9.
9
The application of vagus nerve stimulation and deep brain stimulation in depression.迷走神经刺激和深部脑刺激在抑郁症中的应用。
Neuropsychobiology. 2011;64(3):170-81. doi: 10.1159/000325225. Epub 2011 Jul 29.
10
Vagus nerve stimulation enhances perforant path-CA3 synaptic transmission via the activation of β-adrenergic receptors and the locus coeruleus.迷走神经刺激通过激活β肾上腺素能受体和蓝斑增强穿通纤维-CA3 突触传递。
Int J Neuropsychopharmacol. 2012 May;15(4):523-30. doi: 10.1017/S1461145711000708. Epub 2011 May 17.