Müller Helge H O, Moeller Sebastian, Lücke Caroline, Lam Alexandra P, Braun Niclas, Philipsen Alexandra
Department of Psychiatry and Psychotherapy, Universitätsklinikum Bonn, Bonn, Germany.
Department of Psychiatry and Psychotherapy, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
Front Neurosci. 2018 Apr 10;12:239. doi: 10.3389/fnins.2018.00239. eCollection 2018.
In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepressive and augmentative effects. In long-term treatment, up to two-thirds of patients respond. This mini-review provides a comprehensive overview of augmentation pharmacotherapy and neurostimulation-based treatment strategies, with a special focus on VNS in TRD, and provides practical clinical advice for how to select TRD patients for add-on neurostimulation treatment strategies.
除了电休克疗法（ECT）和重复经颅磁刺激（rTMS）外，迷走神经刺激（VNS）是治疗重度抑郁症的一种已获批准的神经刺激工具。VNS特别用于难治性抑郁症（TRD），并具有抗抑郁和增效作用。在长期治疗中，多达三分之二的患者有反应。本综述全面概述了增效药物治疗和基于神经刺激的治疗策略，特别关注TRD中的VNS，并就如何选择TRD患者进行附加神经刺激治疗策略提供实用的临床建议。
