Harjai Kusum, Bala Anju, Gupta Ravi K, Sharma Radhika
Department of Microbiology, BMS Block, Punjab University, Chandigarh, India
Department of Microbiology, BMS Block, Punjab University, Chandigarh, India.
Pathog Dis. 2013 Oct;69(1):62-65. doi: 10.1111/2049-632X.12050. Epub 2013 Oct 1.
Pseudomonas aeruginosa is well known for its ability to form biofilm on indwelling medical devices. These biofilms are difficult to remove because of their high tolerance to conventional antibiotics. Therefore, there is a need to look for alternative agents such as medicinal plants, which can eradicate or inhibit biofilm effectively. This study evaluated the role of neem in inhibiting biofilm formation by P aeruginosa Factors contributing to adherence and biofilm formation were also studied. Results demonstrated that neem leaves extract was quite effective in disrupting formation and structure of biofilms. Moreover, the level of exopolysaccharide, alginate, hydrophobic interactions and uroepithelial cell attachment, which contributes to biofilm formation, was also affected significantly. Results confirm the effectiveness of neem extract in inhibiting biofilm formation. Such studies can lead to the discovery of safe antimicrobial drugs from natural sources without the risk of resistance.
铜绿假单胞菌以其在植入式医疗器械上形成生物膜的能力而闻名。这些生物膜由于对传统抗生素具有高度耐受性而难以清除。因此，有必要寻找替代药物，如药用植物，它们可以有效根除或抑制生物膜。本研究评估了印楝在抑制铜绿假单胞菌生物膜形成中的作用。对有助于黏附和生物膜形成的因素也进行了研究。结果表明，印楝叶提取物在破坏生物膜的形成和结构方面相当有效。此外，对生物膜形成有贡献的胞外多糖、藻酸盐、疏水相互作用和尿道上皮细胞黏附水平也受到了显著影响。结果证实了印楝提取物在抑制生物膜形成方面的有效性。此类研究可能会促成从天然来源发现安全的抗菌药物，且不存在耐药风险。
