Laboratorio de Neurociencias, Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta, 391 Santiago, Chile.
Mediators Inflamm. 2013;2013:895651. doi: 10.1155/2013/895651. Epub 2013 May 7.
It is widely accepted that cells serving immune functions in the brain, namely, microglia and astrocytes, are important mediators of pathological phenomena observed in Alzheimer's disease. However, it is unknown how these cells initiate the response that results in cognitive impairment and neuronal degeneration. Here, we review the participation of the immune response mediated by glial cells in Alzheimer's disease and the role played by scavenger receptors in the development of this pathology, focusing on the relevance of class A scavenger receptor (SR-A) for A β clearance and inflammatory activation of glial cell, and as a potential target for Alzheimer's disease therapy.
人们普遍认为，在大脑中发挥免疫功能的细胞，即小胶质细胞和星形胶质细胞，是阿尔茨海默病中观察到的病理现象的重要介质。然而，目前尚不清楚这些细胞如何引发导致认知障碍和神经元变性的反应。在这里，我们综述了由神经胶质细胞介导的免疫反应在阿尔茨海默病中的参与作用，以及清道夫受体在这种病理发展中的作用，重点介绍了 A 类清道夫受体 (SR-A) 在清除 Aβ和神经胶质细胞炎症激活方面的相关性，以及作为阿尔茨海默病治疗的潜在靶点。
