Horn T D, Farmer E R
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
J Cutan Pathol. 1990 Jun;17(3):165-70. doi: 10.1111/j.1600-0560.1990.tb00076.x.
A monoclonal antibody to the recently characterized T lymphocyte expressing a T cell receptor bearing gamma and delta chains (TCR gamma/delta) was applied to 60 biopsy specimens spanning a wide range of diagnoses and containing a variable number of T lymphocytes. TCR gamma/delta+ cells were not enriched in the tissues examined, representing between 0-5% of the total CD3 positive T lymphocyte population. TCR gamma/delta+ cells were identified in 27 cases (45%). The distribution of the TCR gamma/delta-bearing cells was remarkable for preferential stratification at upper cutaneous levels, within the epidermis and papillary dermis in some cases of mycosis fungoides. Benign infiltrates lacked a similar pattern. The role of TCR gamma/delta+ cells is uncertain. The data do not reveal a consistent number or distribution of these cells in cutaneous infiltrates.
一种针对最近鉴定出的表达带有γ和δ链的T细胞受体（TCRγ/δ）的T淋巴细胞的单克隆抗体，被应用于60份活检标本，这些标本涵盖了广泛的诊断类型，并且含有数量不等的T淋巴细胞。在所检查的组织中，TCRγ/δ +细胞并未富集，占总CD3阳性T淋巴细胞群体的0-5%。在27例（45%）病例中鉴定出了TCRγ/δ +细胞。在蕈样肉芽肿的某些病例中，带有TCRγ/δ的细胞分布显著，倾向于在上皮浅层进行分层，位于表皮和乳头真皮内。良性浸润缺乏类似的模式。TCRγ/δ +细胞的作用尚不确定。数据并未揭示这些细胞在皮肤浸润中的数量或分布具有一致性。
