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患有心脏病患者体内的心脏干细胞。

Cardiac stem cells in patients with heart disease.

作者信息

Zhao Xiaohui, Huang Lan

机构信息

Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China.

出版信息

Exp Ther Med. 2013 May;5(5):1273-1276. doi: 10.3892/etm.2013.984. Epub 2013 Feb 28.

DOI:10.3892/etm.2013.984
PMID:23737863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3671741/
Abstract

The heart has been regarded as a terminally differentiated organ for decades. There are numerous indicators for the potency of myocardial regeneration, which opens up new avenues for the treatment of heart disease. Cardiac stem cells (CSCs) have been discovered in the human heart and they play a vital role in myocardial regeneration. This review discusses the distribution, properties and proliferation of CSCs in the myocardium of patients with heart disease. Additionally, the potency of myocardial regeneration in patients with heart disease is discussed.

摘要

几十年来，心脏一直被视为一种终末分化器官。心肌再生能力有众多指标，这为心脏病治疗开辟了新途径。人们已在人类心脏中发现心脏干细胞（CSCs），它们在心肌再生中发挥着至关重要的作用。本综述讨论了心脏病患者心肌中CSCs的分布、特性和增殖情况。此外，还讨论了心脏病患者的心肌再生能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf6/3671741/2e4262f8677d/ETM-05-05-1273-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf6/3671741/59ad0c5037a8/ETM-05-05-1273-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf6/3671741/2e4262f8677d/ETM-05-05-1273-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf6/3671741/59ad0c5037a8/ETM-05-05-1273-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf6/3671741/2e4262f8677d/ETM-05-05-1273-g01.jpg

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引用本文的文献

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The Potential Properties of Natural Compounds in Cardiac Stem Cell Activation: Their Role in Myocardial Regeneration.天然化合物在心脏干细胞激活中的潜在特性：在心肌再生中的作用。
Nutrients. 2021 Jan 19;13(1):275. doi: 10.3390/nu13010275.

本文引用的文献

1
Adult stem cell-like tubular cells reside in the corticomedullary junction of the kidney.成体干细胞样肾小管细胞位于肾脏的皮质髓质交界处。
Int J Clin Exp Pathol. 2008 Jan 1;1(3):232-41.
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Cardiac stem cells in the real world.现实世界中的心脏干细胞
J Thorac Cardiovasc Surg. 2008 Mar;135(3):673-8. doi: 10.1016/j.jtcvs.2007.10.024.
3
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.经皮心内膜心肌活检标本来源的心肌球衍生细胞的再生潜能
Circulation. 2007 Feb 20;115(7):896-908. doi: 10.1161/CIRCULATIONAHA.106.655209. Epub 2007 Feb 5.
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[Aortic stenosis].[主动脉瓣狭窄]
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FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes.成纤维细胞生长因子-2控制驻留心脏前体细胞向功能性心肌细胞的分化。
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Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function.犬心脏中的干细胞具有自我更新、克隆形成能力和多能性，可使梗死心肌再生，改善心脏功能。
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Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure.通过激活多能心脏干细胞实现缺血性心力衰竭中的心肌再生。
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8692-7. doi: 10.1073/pnas.0500169102. Epub 2005 Jun 2.
9
Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function.经血管递送的心脏干细胞可穿越血管屏障，再生梗死心肌，并改善心脏功能。
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3766-71. doi: 10.1073/pnas.0405957102. Epub 2005 Feb 25.
10
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages.出生后的Isl1+成心细胞进入完全分化的心肌细胞谱系。
Nature. 2005 Feb 10;433(7026):647-53. doi: 10.1038/nature03215.