Thanou M, Gedroyc W
Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, Stamford Street, London SE1 9NH, UK.
J Drug Deliv. 2013;2013:616197. doi: 10.1155/2013/616197. Epub 2013 May 12.
Ultrasound-mediated drug delivery under the guidance of an imaging modality can improve drug disposition and achieve site-specific drug delivery. The term focal drug delivery has been introduced to describe the focal targeting of drugs in tissues with the help of imaging and focused ultrasound. Focal drug delivery aims to improve the therapeutic profile of drugs by improving their specificity and their permeation in defined areas. Focused-ultrasound- (FUS-) mediated drug delivery has been applied with various molecules to improve their local distribution in tissues. FUS is applied with the aid of microbubbles to enhance the permeability of bioactive molecules across BBB and improve drug distribution in the brain. Recently, FUS has been utilised in combination with MRI-labelled liposomes that respond to temperature increase. This strategy aims to "activate" nanoparticles to release their cargo locally when triggered by hyperthermia induced by FUS. MRI-guided FUS drug delivery provides the opportunity to improve drug bioavailability locally and therefore improve the therapeutic profiles of drugs. This drug delivery strategy can be directly translated to clinic as MRg FUS is a promising clinically therapeutic approach. However, more basic research is required to understand the physiological mechanism of FUS-enhanced drug delivery.
在成像模态的引导下，超声介导的药物递送可以改善药物分布并实现药物的靶向递送。“聚焦药物递送”这一术语已被引入，用于描述借助成像和聚焦超声在组织中对药物进行聚焦靶向。聚焦药物递送旨在通过提高药物在特定区域的特异性和渗透性来改善药物的治疗效果。聚焦超声（FUS）介导的药物递送已应用于各种分子，以改善它们在组织中的局部分布。FUS借助微泡应用，以增强生物活性分子穿过血脑屏障的通透性，并改善药物在脑中的分布。最近，FUS已与对温度升高有反应的MRI标记脂质体联合使用。该策略旨在“激活”纳米颗粒，使其在由FUS诱导的热疗触发时在局部释放其所载药物。MRI引导的FUS药物递送提供了局部提高药物生物利用度的机会，从而改善药物的治疗效果。这种药物递送策略可以直接转化应用于临床，因为MRg FUS是一种很有前景的临床治疗方法。然而，需要进行更多的基础研究来了解FUS增强药物递送的生理机制。
