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跟腱骨化会有遗传因素吗?

Could ossification of the achilles tendon have a hereditary component?

作者信息

Cortbaoui Chawki, Matta Jihad, Elkattah Rayan

机构信息

Department of Orthopedic Surgery and Traumatology, Saint Georges University Medical Center, Balamand University, P.O. Box 166378, Achrafieh, Beirut 1100 2807, Lebanon.

出版信息

Case Rep Orthop. 2013;2013:539740. doi: 10.1155/2013/539740. Epub 2013 Apr 30.

DOI:10.1155/2013/539740
PMID:23738172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3657403/
Abstract

Ossification of the Achilles tendon (OTA) is an unusual clinical condition. It is characterized by the presence of an ossified mass within the fibrocartilaginous substance of the Achilles tendon. The etiology of the ossification of the Achilles tendon is unknown. Review of the literature suggests that its etiology is multifactorial. The major contributing factors are trauma and surgery with other minor causes such as systemic diseases, metabolic conditions, and infections. To our knowledge, no previous reports suggest any genetic/hereditary predisposition in OAT. We report 3 siblings who have OAT with no history of any of the aforementioned predisposing factors. Could OAT have a hereditary component as one of its etiologies?

摘要

跟腱骨化(OTA)是一种罕见的临床病症。其特征是在跟腱的纤维软骨组织内存在一个骨化团块。跟腱骨化的病因尚不清楚。文献回顾表明其病因是多因素的。主要促成因素是创伤和手术,其他次要原因包括全身性疾病、代谢状况和感染。据我们所知,以前没有报告表明跟腱骨化存在任何遗传/遗传易感性。我们报告了3名患有跟腱骨化的兄弟姐妹,他们没有任何上述诱发因素的病史。跟腱骨化是否可能有遗传因素作为其病因之一呢?

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/aed1c38b608b/CRIM.ORTHOPEDICS2013-539740.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/294e3ea3b92c/CRIM.ORTHOPEDICS2013-539740.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/3a7a1344369d/CRIM.ORTHOPEDICS2013-539740.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/bd8f21f1980c/CRIM.ORTHOPEDICS2013-539740.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/71e0a066e370/CRIM.ORTHOPEDICS2013-539740.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/fd540c0d6979/CRIM.ORTHOPEDICS2013-539740.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/e37a22e97778/CRIM.ORTHOPEDICS2013-539740.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/aed1c38b608b/CRIM.ORTHOPEDICS2013-539740.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/294e3ea3b92c/CRIM.ORTHOPEDICS2013-539740.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/3a7a1344369d/CRIM.ORTHOPEDICS2013-539740.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/bd8f21f1980c/CRIM.ORTHOPEDICS2013-539740.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/71e0a066e370/CRIM.ORTHOPEDICS2013-539740.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/fd540c0d6979/CRIM.ORTHOPEDICS2013-539740.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/e37a22e97778/CRIM.ORTHOPEDICS2013-539740.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7e/3657403/aed1c38b608b/CRIM.ORTHOPEDICS2013-539740.007.jpg

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本文引用的文献

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Achilles tendon ossification: pathology, imaging and aetiology.跟腱骨化:病理学、影像学及病因学
Disabil Rehabil. 2008;30(20-22):1651-65. doi: 10.1080/09638280701785866.
2
Ossification of the Achilles tendon--a case report.
Scott Med J. 2005 Nov;50(4):174-5. doi: 10.1177/003693300505000412.
3
Ossification of a ruptured achilles tendon: a case report in a diabetic patient.跟腱断裂后的骨化:1例糖尿病患者的病例报告
J Foot Ankle Surg. 2002 Sep-Oct;41(5):330-4. doi: 10.1016/s1067-2516(02)80053-9.
Extensive Ossification of the Achilles Tendon with and without Acute Fracture: A Scoping Review.
伴或不伴急性骨折的跟腱广泛骨化:一项范围综述
J Clin Med. 2021 Aug 6;10(16):3480. doi: 10.3390/jcm10163480.
4
Heterotopic Ossification of Tendo Achilles: An Uncommon Clinical Entity.跟腱异位骨化:一种罕见的临床病症。
J Orthop Case Rep. 2019;9(2):45-47. doi: 10.13107/jocr.2250-0685.1364.
5
Mkx-Deficient Mice Exhibit Hedgehog Signaling-Dependent Ectopic Ossification in the Achilles Tendons.Mkx 缺陷型小鼠的跟腱中出现 Hedgehog 信号依赖性异位骨化。
J Bone Miner Res. 2019 Mar;34(3):557-569. doi: 10.1002/jbmr.3630. Epub 2019 Feb 25.
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A silent massive ossification of Achilles tendon as a suspected rare late effect of surgery for club foot.跟腱无声的大量骨化,疑似先天性马蹄内翻足手术后罕见的晚期效应。
SAGE Open Med Case Rep. 2018 May 14;6:2050313X18775587. doi: 10.1177/2050313X18775587. eCollection 2018.
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Ossification of the bilateral Achilles tendon: a rare entity.双侧跟腱骨化:一种罕见的情况。
Acta Radiol Open. 2015 Sep 8;4(9):2058460115599184. doi: 10.1177/2058460115599184. eCollection 2015 Sep.
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Ossification of Achilles tendon--report of three cases.跟腱骨化——三例报告
Arch Orthop Trauma Surg. 2002 Sep;122(7):414-7. doi: 10.1007/s00402-002-0412-9. Epub 2002 May 3.
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Skeletal Radiol. 1994 Feb;23(2):127-31. doi: 10.1007/BF00563207.
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Post traumatic ossification of the Achilles tendon.跟腱创伤后骨化
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