Maccrimmon D, Brunet D, Criollo M, Galin H, Lawson J S
Department of Psychiatry, McMaster University, Hamilton, ON, Canada L8S 4L8 ; St. Joseph's Mountain Healthcare Services, 100 West 5th Street, Hamilton, ON, Canada L8N 3K7.
ISRN Psychiatry. 2012 May 10;2012:596486. doi: 10.5402/2012/596486. Print 2012.
Objective. To explore the Quantitative EEG (QEEG) effects of established clozapine therapy regimes compared to those of previous ineffective antipsychotic regimes among 64 chronic (DSM-IV) schizophrenic patients. Methods. Data from 20 EEG channels referenced to linked ears were collected before and during maintenance clozapine therapy (mean duration 1.4 years). Absolute power was calculated in six frequency bands: delta (0.4-3.6 Hz), theta (4.2-7.8 Hz), alpha (8.2-11.8 Hz), beta1 (12.2-15.8 Hz), beta2 (16.2-19.8 Hz), and beta3 (20.2-23.8 Hz). Results. Clozapine augments power globally in the delta and theta bands, but this effect is more pronounced over frontal areas. Beta3 power was reduced. Alpha showed a frontal increase, more pronounced in the right, coupled with a posterior decrease with no net change in overall power. Conclusion. The demonstration of a significant clozapine-induced alpha topographic shift frontally and to the right is a novel discovery that may serve to encourage further investigations of subcortical structures in attempts to better understand the diverse aetiologies and optimal treatments of the schizophrenias.
目的。探讨在64例慢性（DSM-IV）精神分裂症患者中，与先前无效的抗精神病药物治疗方案相比，已确立的氯氮平治疗方案对定量脑电图（QEEG）的影响。方法。在氯氮平维持治疗前及治疗期间（平均疗程1.4年），收集来自20个以双耳相连为参考电极的脑电图通道的数据。计算六个频段的绝对功率：δ波（0.4 - 3.6赫兹）、θ波（4.2 - 7.8赫兹）、α波（8.2 - 11.8赫兹）、β1波（12.2 - 15.8赫兹）、β2波（16.2 - 19.8赫兹）和β3波（20.2 - 23.8赫兹）。结果。氯氮平使δ波和θ波频段的功率整体增强，但这种效应在额叶区域更为明显。β3波功率降低。α波显示额叶功率增加，右侧更明显，同时后部功率降低，整体功率无净变化。结论。氯氮平引起的α波地形图在额叶和右侧发生显著变化，这一发现是新颖的，可能有助于鼓励进一步研究皮层下结构，以更好地理解精神分裂症的多种病因和最佳治疗方法。
