长期外周给予5-羟色胺可抑制大鼠的甲状腺功能。
Chronic peripheral administration of serotonin inhibits thyroid function in the rat.
作者信息
Sullo Alessio, Brizzi Guglielmo, Maffulli Nicola
机构信息
Second University of Naples, Faculty of Medicine and Surgery, Department of Experimental Medicine, Human Physiology Section, Napoli, Italy (GB, AS).
出版信息
Muscles Ligaments Tendons J. 2011 Dec 29;1(2):48-50. Print 2011 Apr.
Abstract
We studied the effect of chronic intraperitoneal (ip) administration of serotonin (5-HT) and thyroid function. We injected daily intraperitoneally for 10 days different doses of 5-HT, and measured plasma thyroid hormones and TSH levels. There was a decrease in the plasma levels of T3 and T4 with medium doses of 5-HT (0.2 and 0.4 mg/Kg bw for T3, and 0.2 for T4). No effects were evidenced on the plasma levels of TSH. In normal environmental conditions, the site action of 5-HT outside the blood-brain barrier is active when the 5-HT is injected at defined doses. This is probably a result of down-regulation independent of the hypothalamus-pituitary-thyroid axis.
摘要
我们研究了慢性腹腔内注射血清素（5-羟色胺，5-HT）对甲状腺功能的影响。我们连续10天每天腹腔内注射不同剂量的5-HT，并测量血浆甲状腺激素和促甲状腺激素（TSH）水平。中等剂量的5-HT（T3为0.2和0.4毫克/千克体重，T4为0.2毫克/千克体重）可使血浆T3和T4水平降低。未发现对血浆TSH水平有影响。在正常环境条件下，当以特定剂量注射5-HT时，血脑屏障外5-HT的作用位点是活跃的。这可能是下丘脑-垂体-甲状腺轴非依赖性下调的结果。
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