蜜橘苷：一种来自“化州橘红”（Citrus grandis 'Tomentosa'）的黄烷酮糖苷。
Melitidin: a flavanone glycoside from Citrus grandis 'Tomentosa'.
作者信息
Zou Wei, Wang Yonggang, Liu Haibin, Luo Yulong, Chen Si, Su Weiwei
机构信息
Key Laboratory of Gene Engineering of the Ministry of Education and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, 510275 Guangzhou, PR China.
出版信息
Nat Prod Commun. 2013 Apr;8(4):457-8.
Citrus grandis 'Tomentosa' is a traditional Chinese medicine, used as an antitussive. In this research, melitidin, a flavanone glycoside, was isolated from this species for the first time by using chromatographic methods. The structure was confirmed through comprehensive analyses of its ultraviolet, infrared, 1H and 13C NMR, HMBC and HMQC spectroscopic and high-resolution mass spectrometric data. Meliditin showed a good antitussive effect on cough induced by citric acid in Guinea pig, suggesting that it was a contributor to the antitussive effect of C. grandis 'Tomentosa'.
化州柚是一种传统中药，用作镇咳药。在本研究中，首次采用色谱法从该物种中分离出一种黄酮苷——蜜橘黄素。通过对其紫外、红外、1H和13C NMR、HMBC和HMQC光谱以及高分辨率质谱数据的综合分析确定了其结构。蜜橘黄素对豚鼠柠檬酸诱导的咳嗽显示出良好的镇咳作用，表明它是化州柚镇咳作用的一个促成因素。
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