Rouaiguia-Bouakkaz Samia, Amira-Guebailia Habiba, Rivière Céline, Delaunay Jean-Claude, Waffo-Téguo Pierre, Mérillon Jean-Michel
Laboratoire de Chimie Appliquée, Université du 8 Mai 1945, Guelma 24000, Algérie.
Nat Prod Commun. 2013 Apr;8(4):485-6.
Furanocoumarins are the major phytoalexins of Ficus carica and are effective natural drug candidates for treatment of several types of cancer and skin disease. The objectives of this study were to analyze and quantify linear furanocoumarins, mainly psoralen and bergapten, in wood and bark of stems from eight Algerian varieties of fig and to establish the differences in the content of these metabolites in the eight local samples. Psoralen and bergapten contents in the stem bark and wood (in microg/g DW) varied respectively from 146.6 to 1110.3 and from 395.7 to 1671.8 for psoralen, and from 114.3 to 524.0 and from 144.2 to 718.6 for bergapten. This study fills a gap in our knowledge of furanocoumarin distribution in different parts of the fig tree. Psoralen and bergapten concentrations were higher in the wood than in the stem bark. Most of the dark fruited fig trees produce these two coumarins more than the green ones.
呋喃香豆素是无花果的主要植保素，是治疗多种癌症和皮肤病的有效天然候选药物。本研究的目的是分析和定量八个阿尔及利亚无花果品种茎干的木材和树皮中的线性呋喃香豆素，主要是补骨脂素和佛手柑内酯，并确定这八个本地样品中这些代谢物含量的差异。补骨脂素在茎皮和木材中的含量（以微克/克干重计）分别为146.6至1110.3以及395.7至1671.8，佛手柑内酯的含量分别为114.3至524.0以及144.2至718.6。本研究填补了我们对无花果不同部位呋喃香豆素分布认识的空白。补骨脂素和佛手柑内酯在木材中的浓度高于茎皮。大多数深色果实的无花果树比绿色果实的无花果树产生的这两种香豆素更多。
