Ibrahim Darah, Hong Lim Sheh, Kuppan Ninthianantham
Industrial Biotechnology Research Laboratory (IBRL), School of Biological Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Nat Prod Commun. 2013 Apr;8(4):493-6.
The antibacterial efficiency of the methanolic extract of Phyllanthus niruri Linn. was investigated against pathogenic bacteria responsible for common infections of skin, and urinary and gastrointestinal tracts. The extract demonstrated antibacterial activities against all the Gram-positive and Gram-negative bacteria tested. The results obtained suggested that at higher concentrations the extract would eradicate the growth of bacterial cells. The bacterial cells, after exposure to the extract, showed complete alteration in their morphology, followed by collapse of the cells beyond repair. The study revealed that the methanolic extract of P. niruri may be an effective antibacterial agent to treat bacterial infections since the extract exhibited significant antimicrobial potency, comparable with that of the standard antibiotic chloramphenicol.
对叶下珠甲醇提取物针对引起皮肤、泌尿道和胃肠道常见感染的病原菌的抗菌效果进行了研究。该提取物对所有测试的革兰氏阳性菌和革兰氏阴性菌均表现出抗菌活性。所得结果表明，在较高浓度下该提取物可根除细菌细胞的生长。细菌细胞在接触提取物后，其形态发生了完全改变，随后细胞崩溃且无法修复。该研究表明，叶下珠甲醇提取物可能是一种治疗细菌感染的有效抗菌剂，因为该提取物表现出显著的抗菌效力，与标准抗生素氯霉素相当。
