Sahgal G, Ramanathan S, Sasidharan S, Mordi M N, Ismail S, Mansor S M
Centre for Drug Research, University Sains Malaysia, 11800 Penang, Malaysia.
Trop Biomed. 2009 Dec;26(3):274-9.
The present study was designed to evaluate the antibacterial activities of Swietenia mahagoni crude methanolic (SMCM) seed extract. The antimicrobial activity of the oily extract against Gram-positive, Gram-negative, yeast and fungus strains was evaluated based on the inhibition zone using disc diffusion assay, minimal inhibition concentration (MIC) and minimal bactericidal concentration (MBC) values. The crude extract was subjected to various phytochemicals analysis. The demonstrated qualitative phytochemical tests exhibited the presences of common phytocompounds including alkaloids, terpenoids, antraquinones, cardiac glycosides, saponins, and volatile oils as major active constituents. The SMCM seed extract had inhibitory effects on the growth of Candida albicans, Staphylococcus aureus, Pseudomonas aeroginosa, Streptococcus faecalis and Proteus mirabillase and illustrated MIC and MBC values ranging from 25 mg/ml to 50 mg/ml.
本研究旨在评估桃花心木粗甲醇（SMCM）种子提取物的抗菌活性。基于纸片扩散法的抑菌圈、最低抑菌浓度（MIC）和最低杀菌浓度（MBC）值，评估了油状提取物对革兰氏阳性菌、革兰氏阴性菌、酵母和真菌菌株的抗菌活性。对粗提取物进行了各种植物化学分析。定性植物化学试验表明，主要活性成分包括生物碱、萜类、蒽醌、强心苷、皂苷和挥发油等常见植物化合物的存在。SMCM种子提取物对白色念珠菌、金黄色葡萄球菌、铜绿假单胞菌、粪肠球菌和奇异变形杆菌的生长具有抑制作用，其MIC和MBC值范围为25mg/ml至50mg/ml。
