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口服碳酸氢钠对盲肠pH值的影响。

Effect of orally administered sodium bicarbonate on caecal pH.

作者信息

Taylor E A, Beard W L, Douthit T, Pohlman L

机构信息

Department of Clinical Sciences, Kansas State University, USA.

出版信息

Equine Vet J. 2014 Mar;46(2):223-6. doi: 10.1111/evj.12111. Epub 2013 Aug 30.

Abstract

REASONS FOR PERFORMING STUDY

Caecal acidosis is a central event in the metabolic cascade that occurs following grain overload. Buffering the caecal acidosis by enterally administered sodium bicarbonate (NaHCO3 ) may be beneficial to affected horses.

OBJECTIVES

To determine the effect and duration of enterally administered NaHCO3 on caecal pH in healthy horses.

STUDY DESIGN

Experimental study using horses with caecal cannulas.

METHODS

Nine horses had been previously fitted with a caecal cannula. Six horses received 1.0 g/kg bwt NaHCO3 and 3 control horses were given 3 l of water via nasogastric tube. Clinical parameters, water consumption, venous blood gases, caecal pH, faecal pH and faecal water content were measured at 6 h intervals over a 36 h study period.

RESULTS

Horses that received enterally administered NaHCO3 had significantly increased caecal pH that lasted the duration of the study. Treated horses increased their water intake, and developed metabolic alkalaemia, significantly increased plasma sodium concentrations and significantly decreased plasma potassium concentrations.

CONCLUSIONS

Enterally administered NaHCO3 may be beneficial in buffering caecal acidosis.

摘要

开展本研究的原因

盲肠酸中毒是谷物超载后发生的代谢级联反应中的核心事件。经肠道给予碳酸氢钠(NaHCO₃)缓冲盲肠酸中毒可能对患病马匹有益。

目的

确定经肠道给予NaHCO₃对健康马匹盲肠pH值的影响及持续时间。

研究设计

使用装有盲肠插管的马匹进行的实验研究。

方法

9匹马先前已安装盲肠插管。6匹马经鼻胃管给予1.0 g/kg体重的NaHCO₃,3匹对照马给予3升水。在36小时的研究期间,每隔6小时测量临床参数、饮水量、静脉血气、盲肠pH值、粪便pH值和粪便含水量。

结果

经肠道给予NaHCO₃的马匹盲肠pH值显著升高,且在研究期间持续存在。接受治疗的马匹饮水量增加,出现代谢性碱血症,血浆钠浓度显著升高,血浆钾浓度显著降低。

结论

经肠道给予NaHCO₃可能有助于缓冲盲肠酸中毒。

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