Banovic Frane, Linder Keith, Boone Alison, Jennings Sam, Murphy K Marcia
Department of Clinical Sciences, NC State University College of Veterinary Medicine, 1052 William Moore Drive, Raleigh, NC 27607, USA.
Vet Dermatol. 2013 Aug;24(4):463-5, e107-8. doi: 10.1111/vde.12038. Epub 2013 Jun 5.
In humans, rapidly developing Pasteurella multocida cellulitis after a cat scratch or bite is a well-known entity that sometimes progresses to necrotizing fasciitis and can be fatal.
A 3-year-old female spayed whippet dog developed ecchymosis, swelling and pain within 24 h of being scratched by a cat on the ventral thorax. Over the following days, while being treated only with pain medications, the lesions rapidly progressed into haemorrhagic bullae with expanding skin necrosis. A heavy growth of P. multocida was seen on bacterial cultures, and histological examination showed marked, suppurative panniculitis with necrosis of the epidermis, dermis and panniculus. Special histological stains highlighted a moderate amount of Gram-negative coccobacilli admixed with inflammatory cells. Complete resolution was achieved with surgical debridement, skin grafting and intravenous antibiotic treatment. Positive bacterial culture for P. multocida, in conjunction with the history, clinical findings, histology results and the rapid response to therapy, strongly supports a diagnosis of P. multocida necrotizing cellulitis.
Complications of cat bite-associated P. multocida infections in humans are well known. To the authors' knowledge, this is the first documentation of P. multocida necrotizing cellulitis in a dog following a cat scratch wound. This case highlights the rapidity and severity of P. multocida cellulitis, if not recognized and treated early. Veterinarians should include P. multocida in the differential diagnosis of any local wound infection following a cat scratch.
在人类中，猫抓或咬伤后迅速发展的多杀巴斯德菌蜂窝织炎是一种众所周知的疾病，有时会进展为坏死性筋膜炎，甚至可能致命。
一只3岁已绝育的惠比特母犬在胸部腹侧被猫抓伤后24小时内出现瘀斑、肿胀和疼痛。在接下来的几天里，尽管仅用止痛药物治疗，但病变迅速发展为出血性大疱，并伴有皮肤坏死扩大。细菌培养发现大量多杀巴斯德菌生长，组织学检查显示有明显的化脓性脂膜炎，伴有表皮、真皮和皮下脂肪坏死。特殊组织学染色显示有中等数量的革兰氏阴性球杆菌与炎症细胞混合。通过手术清创、皮肤移植和静脉抗生素治疗，实现了完全康复。多杀巴斯德菌细菌培养阳性，结合病史、临床发现、组织学结果以及对治疗的快速反应，有力地支持了多杀巴斯德菌坏死性蜂窝织炎的诊断。
猫咬相关的多杀巴斯德菌感染在人类中的并发症是众所周知的。据作者所知，这是首次记录猫抓伤伤口后犬发生多杀巴斯德菌坏死性蜂窝织炎的病例。该病例突出了多杀巴斯德菌蜂窝织炎如果不早期识别和治疗的快速性和严重性。兽医在猫抓伤后任何局部伤口感染的鉴别诊断中应考虑多杀巴斯德菌。
