Hirsch Lawrence J, Gaspard Nicolas
Yale University School of Medicine, 15 York St, LLCI-714, New Haven, CT 06510, USA.
Continuum (Minneap Minn). 2013 Jun;19(3 Epilepsy):767-94. doi: 10.1212/01.CON.0000431395.16229.5a.
This review presents the state of the art in the diagnosis and management of status epilepticus.
In addition to general background, this article presents the most recent findings regarding the diagnosis and treatment of status epilepticus, including the results of the Rapid Anticonvulsant Medication Prior to Arrival Trial (RAMPART) and the available data on the use of newer antiepileptic and anesthetic drugs in the treatment of refractory status epilepticus. It also presents available guidelines such as those from the Neurocritical Care Society.
Despite recent advances, the management of status epilepticus remains a challenge. Rapid treatment, a written treatment protocol, early consideration of nonconvulsive seizures, and avoiding overtreatment and medical complications are the keys to successful management. This article summarizes the current evidence and guidelines.
本综述介绍癫痫持续状态诊断与管理的最新进展。
除一般背景知识外，本文介绍了癫痫持续状态诊断与治疗的最新发现，包括院前快速抗惊厥药物试验（RAMPART）的结果以及新型抗癫痫和麻醉药物用于治疗难治性癫痫持续状态的现有数据。还介绍了可用的指南，如神经重症监护学会发布的指南。
尽管最近有进展，但癫痫持续状态的管理仍然是一项挑战。快速治疗、书面治疗方案、早期考虑非惊厥性癫痫发作以及避免过度治疗和医疗并发症是成功管理的关键。本文总结了当前的证据和指南。
