Institute for History of Pharmacy, Philipps University Marburg, Germany.
Otol Neurotol. 2013 Jul;34(5):795-7. doi: 10.1097/MAO.0b013e31829411d7.
Vinegar and aluminium acetate preparations are used for treatment of ear infections. It is instrumental to know the minimal inhibitory concentration to get effective remedies. This study was performed to assess the lowest dilution of vinegar (specified content, 6% acetic acid) and aluminium acetate-tartrate solution (specified content, 1.4% aluminium and 6% acetic acid) to determine the minimum inhibitory concentration against bacteria commonly found in chronic ear infections.
Laboratory study on 2 samples of aluminium acetate-tartrate and on 1 sample of natural white wine vinegar on antibacterial effects against Staphylococcus aureus, Staphylococcus epidermidis, Proteus vulgaris, Pseudomonas aeruginosa, and Escherichia coli.
Performing of a susceptibility testing-determination of the minimum inhibitory concentration (MIC) with the method of microbouillon dilution (DIN 58940 part 7).
Acetic acid was found to be effective in vitro in concentrations of 0.1% to 0.2% against the tested bacteria; aluminium acetate-tartrate solution was found to be effective in vitro in concentrations of 1.25% to 2.5% against the tested bacteria.
Vinegar respectively acetic acid diluted with water and aqueous aluminium acetate-tartrate solution could be effective ototopic preparations caused by one of the tested bacteria. For its effectiveness, an acid pH not higher than 4.5 is essential. Experiments with aluminium acetate-tartrate preparations on animals and clinical trials are required to obtain information about the response rates in ear infections and about any adverse effects.
醋和醋酸铝制剂被用于治疗耳部感染。了解最小抑菌浓度以获得有效治疗方法是很重要的。本研究旨在评估食用醋（规定含量为 6%乙酸）和醋酸铝酒石酸盐溶液（规定含量为 1.4%铝和 6%乙酸）的最低稀释度，以确定针对慢性耳部感染中常见细菌的最低抑菌浓度。
对 2 种醋酸铝酒石酸盐样本和 1 种天然白葡萄酒醋样本进行实验室研究，以评估其对金黄色葡萄球菌、表皮葡萄球菌、普通变形杆菌、铜绿假单胞菌和大肠杆菌的抗菌效果。
采用微量肉汤稀释法（DIN 58940 第 7 部分）进行药敏试验-最小抑菌浓度（MIC）测定。
发现 0.1%至 0.2%的乙酸在体外对测试细菌有效；1.25%至 2.5%的醋酸铝酒石酸盐溶液在体外对测试细菌有效。
用水稀释的醋和水稀释的醋酸铝酒石酸盐溶液可能是由测试细菌之一引起的局部制剂的有效药物。为了保证其有效性，酸 pH 值不应高于 4.5。需要进行动物实验和临床试验，以获得有关耳部感染的反应率和任何不良反应的信息。
