van der Heide Jaap Homan
Academisch Medisch Centrum, afd. Nefrologie, Amsterdam, the Netherlands.
Ned Tijdschr Geneeskd. 2013;157(23):A6352.
A study recently published in The Lancet investigated the 3-year graft survival of heart-beating (HB) and non-heart-beating (NHB) kidney donors. This was done utilizing the UK registry. The study concluded that donor age affects graft survival. It also demonstrated that NHB kidneys tolerate cold ischemia less well than kidneys from HB donors. Based on these conclusions, it is suggested that a different allocation algorithm should be designed in order to reduce ischemic time for NHB donor kidneys. These findings are relevant to the Dutch situation in which more than 50% of postmortal kidney donors are now NHB. Despite past efforts, ischemic times in the Netherlands can still be improved compared to neighbouring countries. It is proposed that this matter be dealt with prior to changes in the allocation algorithm.
最近发表在《柳叶刀》上的一项研究调查了心脏跳动(HB)和非心脏跳动(NHB)肾脏供体的3年移植物存活率。这项研究利用了英国的登记系统。研究得出结论,供体年龄会影响移植物存活率。研究还表明,与HB供体的肾脏相比,NHB供体的肾脏对冷缺血的耐受性较差。基于这些结论,建议设计一种不同的分配算法,以减少NHB供体肾脏的缺血时间。这些发现与荷兰的情况相关,目前荷兰超过50%的死后肾脏供体为NHB供体。尽管过去做出了努力,但与邻国相比,荷兰的缺血时间仍有改善空间。建议在改变分配算法之前先处理这个问题。