Wijnen R M, Booster M H, Stubenitsky B M, de Boer J, Heineman E, Kootstra G
Department of Surgery, University Hospital, Maastricht, Netherlands.
Lancet. 1995 Apr 29;345(8957):1067-70.
To reduce the shortage of kidneys for transplantation, we started a non-heart-beating (NHB) donor programme, and compared the short-term and long-term outcomes of kidneys from NHB donors with those of a matched group of kidneys from heart-beating (HB) donors. 57 NHB kidneys were procured at the University Hospital in Maastricht and at three regional hospitals in the Netherlands, and were transplanted in 21 transplant centres within the Eurotransplant exchange organisation. 114 matched controls from HB donors were selected from Eurotransplant files. Mean follow-up was 85 months. At 5 years, graft survival was 54% for NHB kidneys and 55% for HB kidneys; patient survival was 75% and 77%. Kidneys from NHB donors had a significantly higher rate of delayed graft function (60% vs 35%), resulting in a longer hospital stay. Primary non-function of the graft was seen as frequently in the NHB donor-kidney group as in the HB group (14% vs 8%, p = 0.3). We conclude that NHB donors are a valuable source of kidneys for transplantation.
为减少肾脏移植供体的短缺，我们启动了一项非心脏跳动（NHB）供体计划，并将NHB供体肾脏的短期和长期结果与一组匹配的心脏跳动（HB）供体肾脏的结果进行了比较。在马斯特里赫特大学医院和荷兰的三家地区医院获取了57个NHB肾脏，并在欧洲移植交换组织内的21个移植中心进行了移植。从欧洲移植档案中选取了114个来自HB供体的匹配对照。平均随访时间为85个月。5年后，NHB肾脏的移植肾存活率为54%，HB肾脏为55%；患者存活率分别为75%和77%。NHB供体的肾脏移植肾功能延迟发生率显著更高（60%对35%），导致住院时间更长。移植肾原发性无功能在NHB供体肾脏组和HB组中的发生率相当（14%对8%，p = 0.3）。我们得出结论，NHB供体是移植肾脏的宝贵来源。
