Maio Paula, Bento Diogo, Vieira Raquel, Afonso Ana, Sachse Fernanda, Kutzner Heinz
Curry Cabral Hospital, Central Lisbon Hospital Center EPE, Lisbon, Portugal.
An Bras Dermatol. 2013 Mar-Apr;88(2):264-7. doi: 10.1590/S0365-05962013000200016.
Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.
细胞毒性淋巴瘤包括一系列外周T细胞淋巴瘤，这些淋巴瘤可以有首发或晚期皮肤表现。我们描述了一名来自佛得角的46岁男性，其皮肤病累及面部和躯干，表现为表面光滑的单形性丘疹以及运动和感觉性多发性神经病变。麻风的诊断假设得到了临床和初始组织病理学检查结果的支持，该患者因疑似汉森病被转诊至我院。在新的皮肤和淋巴结活检中，发现了一个淋巴细胞群体，其免疫组织化学研究确诊为表达细胞毒性标志物的T细胞淋巴瘤。患者开始接受化疗，皮肤病变最初缓解，但随后出现全身疾病进展。
