Marti R M, Estrach T, Palou J, Urbano-Ispizua A, Gratacos J, Cervera R, Feliu E, Grau J M, Mascaro J M
Department of Dermatology, Hospital Clinic i Provincial, Universidad de Barcelona, Spain.
Int J Dermatol. 1992 Sep;31(9):624-8. doi: 10.1111/j.1365-4362.1992.tb03979.x.
Histopathologic, immunohistochemical, and ultrastructural studies were carried out on cutaneous lesions of a 43-year-old man with an aggressive peripheral T-cell lymphoma involving the lung, central nervous system, bone marrow, and skin. Some results are distinctive and not previously reported, such as extremely strong epidermotropism, aberrant CD8+ immunophenotype with lack of one pan T antigen (CD5), and giant cytoplasmic granules. We discuss these features comparing them with other hematologic malignancies usually involving the skin, such as cutaneous T-cell lymphoma, adult T-cell leukemia/lymphoma, angiocentric lymphomas, and malignant histiocytosis.
