Department of Geriatrics, Policlinico A. Gemelli, Catholic University of the Sacred Heart, Rome, Italy.
Aging Clin Exp Res. 2013 May;25(2):119-27. doi: 10.1007/s40520-013-0030-0. Epub 2013 Apr 4.
In terms of managing sarcopenia, many studies have shown that physical activity (in particular resistance exercise) and specific nutrition interventions such as protein and amino acids supplementation can improve muscle mass and strength in older adults. Moreover, several drugs have been suggested to have an impact on muscle outcomes, with various levels of scientific evidence. In the present paper we have reviewed the evidence regarding the effect of some new metabolic agents (vitamin D, leucine, β-hydroxy β-methylbutyrate, citrulline malate, ornithine, isoflavones) on sarcopenia and muscular outcomes in older adults. For each metabolic agent, we have also discussed the biological plausibility of the described effect.
在管理肌少症方面，许多研究表明，身体活动（特别是抗阻运动）和特定的营养干预措施，如蛋白质和氨基酸补充，可以改善老年人的肌肉量和力量。此外，已有几种药物被认为对肌肉结果有影响，但科学证据水平不同。在本文中，我们回顾了一些新的代谢剂（维生素 D、亮氨酸、β-羟基-β-甲基丁酸、柠檬酸苹果酸、精氨酸、异黄酮）对老年人肌少症和肌肉结果的影响的证据。对于每种代谢剂，我们还讨论了所描述的作用的生物学合理性。
