Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 North Walnut Street, Room 1036 WARF, Madison, WI 53726.
J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):207-14. doi: 10.1093/gerona/glt075. Epub 2013 Jun 5.
Although research has linked systemic inflammation to various diseases of aging, few studies have examined the potential role it may play in the development of age-related hearing impairment.
Among 1,073 participants free of hearing impairment (pure-tone average 0.5, 1, 2, 4kHz ≤ 25 dB HL) in the population-based Epidemiology of Hearing Loss Study (1998-2000), serum C-reactive protein, and interleukin-6 were measured at three time points (1988-1990, 1998-2000, and 2009-2010), and tumor necrosis factor-α was measured at one time point (1998-2000), whereas hearing impairment was measured again in 2003-2005 and 2009-2010 to determine the 10-year cumulative incidence.
Inflammatory marker levels from a single time point (1998-2000) were not associated with an increased risk of developing hearing impairment. Associations between long-term serum C-reactive protein levels and incident hearing impairment differed by age (p = .031). Participants less than 60 years with consistently high (>3 mg/L) or increasing levels of serum C-reactive protein over 10 years were nearly two times (hazard ratio: 1.96, 95% confidence interval: 1.19, 3.23) as likely to develop hearing impairment over the subsequent 10-year period, an association not seen in participants more than or equal to 60 years. A statistically significant association (p-trend = .041) was also observed between number of markers in the highest group at baseline and incident hearing impairment in this younger age group.
Associations between long-term serum C-reactive protein levels and incident hearing impairment were observed in the cohort as a whole, but differed significantly by age group, with statistically significant associations observed in adults less than 60 years, participants moving through the peak risk period for hearing impairment over the course of the study.
虽然研究已经将系统性炎症与各种衰老相关疾病联系起来，但很少有研究研究其在与年龄相关的听力障碍发展中的潜在作用。
在基于人群的听力损失研究（1998-2000 年）中，共有 1073 名无听力障碍的参与者（纯音平均 0.5、1、2、4kHz≤25dBHL），在三个时间点（1988-1990 年、1998-2000 年和 2009-2010 年）测量血清 C 反应蛋白和白细胞介素-6 的水平，而肿瘤坏死因子-α则在一个时间点（1998-2000 年）测量，而听力障碍则在 2003-2005 年和 2009-2010 年再次测量，以确定 10 年的累积发病率。
单次时间点（1998-2000 年）的炎症标志物水平与听力障碍风险增加无关。长期血清 C 反应蛋白水平与新发听力障碍之间的关系因年龄而异（p=0.031）。10 年内持续高水平（>3mg/L）或血清 C 反应蛋白水平升高的参与者，年龄小于 60 岁的参与者发生听力障碍的风险几乎增加两倍（危险比：1.96，95%置信区间：1.19，3.23），而年龄大于或等于 60 岁的参与者则未见此关联。在这个年轻组中，也观察到基线时最高组标志物数量与新发听力障碍之间存在统计学显著相关性（p 趋势=0.041）。
在整个队列中观察到长期血清 C 反应蛋白水平与新发听力障碍之间存在关联，但按年龄组差异显著，在年龄小于 60 岁的成年人中观察到统计学显著关联，参与者在研究过程中经历了听力障碍的高峰风险期。
