Intensive Care and Department of Paediatric Surgery, Erasmus Medical Center-Sophia Children's Hospital, Room Sk 1280; dr. Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands.
Intensive Care Med. 2013 Sep;39(9):1584-93. doi: 10.1007/s00134-013-2973-1. Epub 2013 Jun 6.
Reporting neurodevelopmental outcome of 8-year-old children treated with neonatal extracorporeal membrane oxygenation (ECMO).
In a follow-up study in 135 8-year-old children who received neonatal ECMO between 1996 and 2001 we assessed intelligence (Revised Amsterdam Intelligence Test), concentration (Bourdon-Vos test), eye-hand coordination (Developmental Test of Visual-Motor Integration) and behavior (Child Behavior Checklist and Teacher Report Form).
Intelligence fell within normal range (mean IQ 99.9, SD 17.7, n = 125) with 91 % of the children following regular education. Significantly more children attended special education (9 %) or received extra support in regular education (39 %) compared with normative data. Slower working speed (χ(2) = 132.36, p < 0.001) and less accuracy (χ(2) = 12.90, p < 0.001) were found on the Bourdon-Vos test (n = 123) compared with normative data. Eye-hand coordination fell within the normal range (mean 97.6, SD 14.3, n = 126); children with congenital diaphragmatic hernia scored lowest but still normally (mean 91.0, SD 16.4, n = 28). Mothers (n = 117) indicated more somatic and attention behavior problems; teachers (n = 115) indicated more somatic, social, thought, aggression and total problems compared with normative data. Mothers indicated more somatic problems than teachers (p = 0.003); teachers reported more attention problems than mothers (p = 0.036; n = 111).
Eight-year-old children treated with neonatal ECMO fall in the normal range of intelligence with problems with concentration and behavior. Long-term follow-up for children treated with neonatal ECMO should focus on early detection of (subtle) learning deficits.
报告接受新生儿体外膜肺氧合（ECMO）治疗的 8 岁儿童的神经发育结局。
在对 1996 年至 2001 年间接受新生儿 ECMO 治疗的 135 名 8 岁儿童进行的一项随访研究中，我们评估了智力（修订后的阿姆斯特丹智力测验）、注意力（Bourdon-Vos 测试）、手眼协调能力（视觉运动统合发育测试）和行为（儿童行为检查表和教师报告表）。
智力处于正常范围（平均智商 99.9，标准差 17.7，n = 125），91%的儿童接受正规教育。与正常数据相比，有更多的儿童接受特殊教育（9%）或在正规教育中接受额外支持（39%）。与正常数据相比，Bourdon-Vos 测试（n = 123）中发现的工作速度较慢（χ(2) = 132.36，p < 0.001）和准确性较低（χ(2) = 12.90，p < 0.001）。手眼协调能力处于正常范围（平均 97.6，标准差 14.3，n = 126）；患有先天性膈疝的儿童得分最低，但仍在正常范围内（平均 91.0，标准差 16.4，n = 28）。母亲（n = 117）报告了更多的躯体和注意力行为问题；教师（n = 115）报告了更多的躯体、社会、思维、攻击和总问题，与正常数据相比。与教师相比，母亲报告了更多的躯体问题（p = 0.003）；教师报告的注意力问题比母亲多（p = 0.036；n = 111）。
接受新生儿 ECMO 治疗的 8 岁儿童的智力处于正常范围，但注意力和行为存在问题。接受新生儿 ECMO 治疗的儿童的长期随访应重点关注早期发现（细微）学习缺陷。
