Schaffler K, Wolf O T, Burkart M
HPR Dr. Schaffler GmbH, Aschheim-Dornach, Germany. k.schaffl
Pharmacopsychiatry. 2013 Jul;46(5):181-90. doi: 10.1055/s-0033-1347178. Epub 2013 Jun 5.
Plant adaptogens are traditionally used for stress-related symptoms, but clinical evidence is inconsistent. This trial explored the effects of 120 mg/day Eleutherococcus senticosus root extract (ES), 2-day professional stress management training (SMT) and a combination of both (COM).
144 participants suffering from asthenia and reduced working capacity related to chronic stress were randomized to the treatments. Validated scales and tests were used to investigate cognitive performance; feeling stressed; fatigue and exhaustion; alertness, restlessness and mood; quality of life and sleep; physical complaints and activities; and physiological stress parameters including cortisol awakening response (CAR), at baseline, after 2 and 8 weeks of treatment (German Clinical Trials Register DRKS00000692).
Almost all parameters improved significantly over time without group differences. Significant differences were found in mental fatigue and restlessness, both in favor of COM vs. ES. COM was not superior to SMT in any parameter at week 8. An attenuation of the CAR was seen at week 2 without group differences. All treatments were well tolerated.
Effects of adding ES to SMT are, if any, negligible.
植物适应原传统上用于治疗与压力相关的症状，但临床证据并不一致。本试验探讨了每日120毫克刺五加根提取物（ES）、为期2天的专业压力管理培训（SMT）以及两者结合（COM）的效果。
144名患有与慢性压力相关的乏力和工作能力下降的参与者被随机分配接受治疗。使用经过验证的量表和测试来调查认知表现；压力感受；疲劳与倦怠；警觉性、烦躁不安和情绪；生活质量和睡眠；身体不适与活动；以及生理压力参数，包括皮质醇觉醒反应（CAR），在基线、治疗2周和8周后进行评估（德国临床试验注册DRKS00000692）。
几乎所有参数随时间显著改善，且无组间差异。在精神疲劳和烦躁不安方面发现了显著差异，两者均显示COM组优于ES组。在第8周时，COM组在任何参数上均不优于SMT组。在第2周时观察到CAR有所减弱，但无组间差异。所有治疗耐受性良好。
在SMT中添加ES的效果即使有，也可忽略不计。
