Drozd Janina, Sawicka Teresa, Prosińska Joanna
Department of Biological Preparations, Drug Institute, 30/34 Chełmska Str., 00-725 Warszawa.
Acta Pol Pharm. 2002 Sep-Oct;59(5):395-401.
The aim of the present work was an estimation of the influence of two plant pharmaceutical preparations containing an extract from the root of Eleutherococcus senticosus: Argoeleuter tablets and Immuplant tablets, on the humoral response of immunological system. Experiments were performed with female Balb/c mice six weeks old. In order to reveal the influence of taking preparations, containing an extract from Eleutherococcus senticosus on some elements of the immunological system, three ways of their administration have been compared: before illness, during illness and a combination of both. The obtained results allow formulating the following conclusions: - the pharmaceutical preparations, containing the extract from Eleutherococcus senticosus administered orally, influence on the increase of the level of immunoglobulins comprised in the mice's blood serum, - the pharmaceutical preparations act with different power, not fully dependent on the content of marker of the active substance - eleutheroside E, - dosage of the preparations containing the extract from Eleutherococcus senticosus should not be established basing only on the extract content, - best curative results, measured as the stimulation of humoral response of the organism were obtained when a given preparation was administered therapeutically, even though the combined administration - prophylactically with prolonged administration during illness also is correct.
本研究的目的是评估两种含有刺五加根提取物的植物药物制剂——阿戈埃勒特片和免疫增强片，对免疫系统体液反应的影响。实验使用六周龄的雌性Balb/c小鼠进行。为了揭示服用含有刺五加提取物的制剂对免疫系统某些元素的影响，比较了三种给药方式：发病前、发病期间以及两者结合。获得的结果可得出以下结论：——口服含有刺五加提取物的药物制剂，会影响小鼠血清中免疫球蛋白水平的升高；——药物制剂的作用强度不同，并不完全取决于活性物质刺五加苷E的含量；——含有刺五加提取物的制剂的剂量不应仅基于提取物含量来确定；——当给定制剂进行治疗性给药时，即使预防性联合给药并在发病期间长期给药也是正确的，但以刺激机体体液反应来衡量，仍能获得最佳治疗效果。
