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Pediatr Obes. 2013 Oct;8(5):e50-3. doi: 10.1111/j.2047-6310.2013.00178.x. Epub 2013 Jun 6.
2
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Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls.中国女孩中LIN28B基因周围的基因多态性与特发性中枢性性早熟风险的关联。
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Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.男性和女性性成熟的全基因组关联研究突出了体重和初潮基因座在男性青春期中的作用。
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Distinct variants at LIN28B influence growth in height from birth to adulthood.LIN28B 的不同变异体影响从出生到成年的身高增长。
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Interactions between Polygenic Risk Scores, Dietary Pattern, and Menarche Age with the Obesity Risk in a Large Hospital-Based Cohort.多基因风险评分、饮食模式与初潮年龄在大型基于医院队列中与肥胖风险的相互作用。
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引用本文的文献

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Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.初潮年龄的遗传决定因素：LIN28B基因起作用吗？一篇综述。
Hormones (Athens). 2025 Mar;24(1):167-177. doi: 10.1007/s42000-024-00594-3. Epub 2024 Sep 4.
2
Study of , , and Polymorphisms of in Relation to Age at Menarche in Girls of Greek Descent.希腊裔女孩初潮年龄与[具体基因名称]的[具体基因位点1]、[具体基因位点2]和[具体基因位点3]多态性的研究
Children (Basel). 2024 Jul 29;11(8):912. doi: 10.3390/children11080912.
3
Genetics of pubertal timing.青春期启动的遗传学。
Curr Opin Pediatr. 2018 Aug;30(4):532-540. doi: 10.1097/MOP.0000000000000642.
4
Association of genetic polymorphisms around the LIN28B gene and idiopathic central precocious puberty risks among Chinese girls.中国女孩中LIN28B基因周围的基因多态性与特发性中枢性性早熟风险的关联。
Pediatr Res. 2016 Oct;80(4):521-5. doi: 10.1038/pr.2016.107. Epub 2016 May 13.
5
The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity.普通人群青春期发育时间的遗传学：最新进展及性别特异性证据。
Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):57-65. doi: 10.1097/MED.0000000000000213.

本文引用的文献

1
Association of LIN28B with adult adiposity-related traits in females.LIN28B 与女性肥胖相关特征的关联。
PLoS One. 2012;7(11):e48785. doi: 10.1371/journal.pone.0048785. Epub 2012 Nov 13.
2
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.复制影响西班牙裔女性初潮和绝经年龄的基因座：妇女健康倡议 SHARe 研究。
Hum Mol Genet. 2012 Mar 15;21(6):1419-32. doi: 10.1093/hmg/ddr570. Epub 2011 Nov 30.
3
Population-specific coding variant underlies genome-wide association with adiponectin level.特定人群的编码变异是导致脂联素水平与全基因组关联的基础。
Hum Mol Genet. 2012 Jan 15;21(2):463-71. doi: 10.1093/hmg/ddr480. Epub 2011 Oct 18.
4
Familial concordance for age at menarche: analyses from the Breakthrough Generations Study.家族性初潮年龄一致性：突破性世代研究分析。
Paediatr Perinat Epidemiol. 2011 May;25(3):306-11. doi: 10.1111/j.1365-3016.2010.01183.x. Epub 2011 Jan 14.
5
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.通过全基因组关联研究的荟萃分析发现了 30 个新的月经初潮年龄相关基因座。
Nat Genet. 2010 Dec;42(12):1077-85. doi: 10.1038/ng.714.
6
Determinants of menarche.初潮的决定因素。
Reprod Biol Endocrinol. 2010 Sep 30;8:115. doi: 10.1186/1477-7827-8-115.
7
Distinct variants at LIN28B influence growth in height from birth to adulthood.LIN28B 的不同变异体影响从出生到成年的身高增长。
Am J Hum Genet. 2010 May 14;86(5):773-82. doi: 10.1016/j.ajhg.2010.03.010. Epub 2010 Apr 15.
8
Early age at menarche associated with cardiovascular disease and mortality.初潮年龄与心血管疾病和死亡率有关。
J Clin Endocrinol Metab. 2009 Dec;94(12):4953-60. doi: 10.1210/jc.2009-1789. Epub 2009 Oct 30.
9
Genetic variation in LIN28B is associated with the timing of puberty.LIN28B 基因变异与青春期开始时间有关。
Nat Genet. 2009 Jun;41(6):729-33. doi: 10.1038/ng.382. Epub 2009 May 17.
10
Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.全基因组关联研究鉴定出与初潮年龄相关的 6q21 上的序列变异。
Nat Genet. 2009 Jun;41(6):734-8. doi: 10.1038/ng.383. Epub 2009 May 17.

菲律宾年轻女性中LIN28B基因单核苷酸多态性与初潮年龄关联的重复研究。

Replication of LIN28B SNP association with age of menarche in young Filipino women.

作者信息

Croteau-Chonka D C, Lange L A, Lee N R, Adair L S, Mohlke K L

机构信息

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.

出版信息

Pediatr Obes. 2013 Oct;8(5):e50-3. doi: 10.1111/j.2047-6310.2013.00178.x. Epub 2013 Jun 6.

DOI:10.1111/j.2047-6310.2013.00178.x
PMID:23740805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3772980/
Abstract

BACKGROUND

Age of menarche, or the timing of first menses in girls, is a physiological trait that shows substantial genetic heritability. Earlier age of menarche is associated with increased childhood adiposity and with adult risk of obesity and cardiovascular disease.

OBJECTIVES

We sought to further characterize the single nucleotide polymorphism (SNP) rs7759938 from the menarche locus LIN28B in 827 young Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS).

METHODS

We tested rs7759938 for additive association with age of menarche and also tested whether childhood adiposity, as measured by body mass index (BMI) at age 8, mediated this relationship.

RESULTS

We observed nominal association of rs7759938 with age of menarche (β = -0.118 years, 95% confidence interval = (-0.216, -0.020), P = 0.019) with an effect direction consistent with the previous report. We also observed suggestive evidence that the effect of the SNP on age of menarche was independent of childhood BMI.

CONCLUSIONS

These data confirm the strongest gene reported in Europeans (LIN28B) as a contributor to age of menarche in an Asian population.

摘要

背景

初潮年龄，即女孩首次月经的时间，是一种具有显著遗传遗传性的生理特征。初潮年龄较早与儿童期肥胖增加以及成人肥胖和心血管疾病风险增加有关。

目的

我们试图在来自宿务纵向健康与营养调查（CLHNS）的827名年轻菲律宾女性中，进一步表征初潮位点LIN28B的单核苷酸多态性（SNP）rs7759938。

方法

我们测试了rs7759938与初潮年龄的加性关联，并测试了8岁时通过体重指数（BMI）衡量的儿童期肥胖是否介导了这种关系。

结果

我们观察到rs7759938与初潮年龄存在名义上的关联（β = -0.118岁，95%置信区间 = （-0.216，-0.020），P = 0.019），效应方向与先前报告一致。我们还观察到提示性证据，表明该SNP对初潮年龄的影响独立于儿童期BMI。

结论

这些数据证实了欧洲人报道的最强基因（LIN28B）在亚洲人群中也是初潮年龄的一个影响因素。