希腊裔女孩初潮年龄与[具体基因名称]的[具体基因位点1]、[具体基因位点2]和[具体基因位点3]多态性的研究

Study of , , and Polymorphisms of in Relation to Age at Menarche in Girls of Greek Descent.

作者信息

Tsinopoulou Vasiliki Rengina, Bacopoulou Flora, Fidani Liana, Dimitriadis Dimitrios, Gerou Spyridon, Christoforidis Athanasios

机构信息

2nd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University General Hospital AHEPA, 54636 Thessaloniki, Greece.

Center for Adolescent Medicine and UNESCO Chair in Adolescent Health Care, 1st Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 11527 Athens, Greece.

出版信息

Children (Basel). 2024 Jul 29;11(8):912. doi: 10.3390/children11080912.

DOI:10.3390/children11080912

PMID:39201847

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11352753/

Abstract

BACKGROUND

Single-nucleotide polymorphisms in , critical regulators of female growth and puberty, have been linked to age at menarche.

METHODS

We assessed the association of , , and with menarcheal age in girls of Greek descent. We reviewed the records of 248 girls who had their first menstruation before 18 years and who attended the Greek Departments of Pediatric Endocrinology from January 2021 to July 2023. Genotyping was performed by standard DNA-based methods. Association analyses involved both parametric and non-parametric tests.

RESULTS

The average age of breast and pubic hair development was 9.95 years, and the age at menarche was 11.55 years. Menarche occurred ≤11 years (mean 10.24 years) in 108 girls (43.5%) and >11 years (mean 12.55 years) in 140 (56.5%). The girls' menarcheal age correlated significantly with that of their mothers (average 12.1 years, -value < 0.0001, Spearman's r 0.350). The dominant genotype was the most common (55.2%), followed by the dominant (53.2%) and dominant (14.5%) genotypes.

CONCLUSIONS

There was no association between age at menarche and any of the polymorphism genotypes/alleles or between genotypes/alleles and birth weight, gestational week, mode of delivery, and maternal age at menarche. Future large sample studies are warranted to confirm these results.

摘要

背景

作为女性生长和青春期的关键调节因子，其单核苷酸多态性与初潮年龄有关。

方法

我们评估了、和与希腊裔女孩初潮年龄之间的关联。我们回顾了248名在18岁之前首次月经来潮且于2021年1月至2023年7月在希腊儿科内分泌科就诊的女孩的记录。基因分型通过基于DNA的标准方法进行。关联分析涉及参数检验和非参数检验。

结果

乳房和阴毛发育的平均年龄为9.95岁，初潮年龄为11.55岁。108名女孩（43.5%）的初潮发生在≤11岁（平均10.24岁），140名女孩（56.5%）的初潮发生在>11岁（平均12.55岁）。女孩的初潮年龄与其母亲的初潮年龄显著相关（平均12.1岁，-值<0.0001，Spearman相关系数r为0.350）。显性基因型最为常见（55.2%），其次是显性（53.2%）和显性（14.5%）基因型。