星状神经节阻滞对咽喉反流病的影响。

Effect of stellate ganglion block on laryngopharyngeal reflux disease.

机构信息

Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital, College of Medicine, Soonchunhyang University, Cheonan, Korea.

出版信息

Korean J Anesthesiol. 2013 May;64(5):439-42. doi: 10.4097/kjae.2013.64.5.439. Epub 2013 May 24.

DOI:10.4097/kjae.2013.64.5.439

PMID:23741567

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3668106/

Abstract

BACKGROUND

Laryngopharyngeal reflux (LPR) disease has many symptoms such as globus pharyngeus, excessive throat clearing and hoarseness. The aim of this study was to investigate the effect of stellate ganglion block (SGB) in addition to proton pump inhibitors (PPI) on LPR.

METHODS

Fifty patients complaining of more than 3 typical LPR symptoms for over 3 months were enrolled in the study. The P group took PPI for 8 weeks. The SP group took PPI and interwent a series of 8 SGB procedure once a week during the period of treatment. The blocks were performed one at a time unilaterally on the right and left stellate ganglions by injecting 1% mepivacaine 6 ml. We evaluated the reflux symptom index (RSI) before treatment and following 4 weeks and 8 weeks of treatment in both groups.

RESULTS

After 4 weeks of treatment, the RSI of the P group decreased, but not significantly, to 16.6 ± 6.8 compared with the baseline value of 19.2 ± 2.7 (P = 0.093), whereas the RSI of the SP group decreased significantly to 9.8 ± 3.3 compared with the baseline value of 19.0 ± 4.7 (P = 0.000). After 8 weeks of treatment, the RSI of the P group decreased significantly to 13.7 ± 6.7 (P = 0.001) and the RSI of the SP group also decreased significantly to 7.7 ± 3.4 (P = 0.000). There were significant differences in the RSI between the two groups after 4 weeks (P = 0.000) and 8 weeks (P = 0.001) of treatment.

CONCLUSIONS

The symptoms of LPR improved earlier when PPI therapy was combined with SGB compared with PPI therapy alone.

摘要

背景

咽反流（LPR）疾病有许多症状，如咽部异物感、频繁清嗓和声音嘶哑。本研究旨在探讨星状神经节阻滞（SGB）联合质子泵抑制剂（PPI）治疗 LPR 的效果。

方法

本研究共纳入 50 例 LPR 症状持续 3 个月以上的患者。P 组接受 PPI 治疗 8 周，SP 组在治疗期间每周接受一次 SGB 治疗，共 8 次，每次在右侧和左侧星状神经节各注射 1%甲哌卡因 6ml。我们在治疗前和治疗后 4 周和 8 周评估两组的反流症状指数（RSI）。

结果

治疗 4 周后，P 组的 RSI 虽有所下降，但与治疗前的 19.2 ± 2.7 相比差异无统计学意义（P = 0.093），为 16.6 ± 6.8；而 SP 组的 RSI 明显下降至 9.8 ± 3.3，与治疗前的 19.0 ± 4.7 相比差异有统计学意义（P = 0.000）。治疗 8 周后，P 组的 RSI 明显下降至 13.7 ± 6.7（P = 0.001），SP 组的 RSI 也明显下降至 7.7 ± 3.4（P = 0.000）。治疗 4 周和 8 周后，两组的 RSI 差异均有统计学意义（P 值分别为 0.000 和 0.001）。