Park Kyoung Sik, Lee Kyu Eun, Ku Do Hoon, Kim Su-Jin, Park Won Seo, Kim Hoon Yub, Kwon Mi Ra, Youn Yeo-Kyu
Department of Surgery, Konkuk University School of Medicine, Seoul, Korea.
J Korean Surg Soc. 2013 Jun;84(6):321-9. doi: 10.4174/jkss.2013.84.6.321. Epub 2013 May 28.
To evaluate the antiadhesive effects and safety of an oxidized regenerated cellulose (Interceed) after thyroidectomy.
Seventy-six thyroidectomized patients were prospectively randomized into two groups with regard to the use of Interceed. We evaluated each group for their adhesive symptoms using four subjective and four objective items at the 2nd week, 3rd and 6th month after thyroidectomy. All patients were examined for vocal cord motility by indirect laryngoscope at each period.
Total adhesion scores at each postoperative follow-up period decreased with time, but were not significantly different in each group. The median score for swallowing discomfort for liquid was significantly lower in the Interceed group than in the control group 2 weeks after surgery. In addition, the severity of skin adhesion to the trachea was reduced in the Interceed group compared with the control group 6 months after surgery. During the study, there were no adverse effects or significant differences in postoperative complications between the groups.
Interceed appeared to be safe and effective in improving neck discomfort at early postoperative periods and preventing skin adhesion to the trachea 6 months after thyroidectomy.
评估氧化再生纤维素（Interceed）在甲状腺切除术后的抗粘连效果及安全性。
76例甲状腺切除患者根据是否使用Interceed被前瞻性随机分为两组。在甲状腺切除术后第2周、第3个月和第6个月，我们使用4项主观指标和4项客观指标对每组患者的粘连症状进行评估。在每个时间段，所有患者均通过间接喉镜检查声带活动度。
术后各随访期的总粘连评分随时间下降，但两组间无显著差异。术后2周，Interceed组液体吞咽不适的中位评分显著低于对照组。此外，术后6个月，Interceed组与对照组相比，皮肤与气管的粘连程度减轻。研究期间，两组间无不良反应，术后并发症也无显著差异。
Interceed在改善术后早期颈部不适以及预防甲状腺切除术后6个月皮肤与气管粘连方面似乎是安全有效的。
