可乐果种子提取物对大鼠扑热息痛诱导的肝毒性的保护作用。

Protective effects of Garcinia kola seed extract against paracetamol-induced hepatotoxicity in rats.

作者信息

Akintonwa A, Essien A R

机构信息

Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.

出版信息

J Ethnopharmacol. 1990 May;29(2):207-11. doi: 10.1016/0378-8741(90)90057-z.

DOI:10.1016/0378-8741(90)90057-z

PMID:2374432

Abstract

The hepatoprotective effect of Garcinia kola seed extract was investigated in rats treated with high doses of paracetamol. The extracts when administered at 100 mg/kg three times a day for five consecutive days reduced paracetamol- (800, 1000, 1200 mg/kg) induced lethality from 50, 90 and 100% to 0, 20 and 40%, respectively. There was a significant reduction in the liver enzymes SGOT and SGPT and histology scores. The hepatoprotective effect of the extract may be due to inhibition of cytochrome P-450 which normally converts paracetamol to the toxic intermediate metabolite N-acetyl-p-benzoquinoneimine (NAPQI).

摘要

在给予高剂量扑热息痛的大鼠中研究了可乐果种子提取物的肝保护作用。提取物以100 mg/kg的剂量连续五天每天给药三次，可将扑热息痛（800、1000、1200 mg/kg）诱导的致死率分别从50%、90%和100%降至0%、20%和40%。肝酶谷草转氨酶（SGOT）和谷丙转氨酶（SGPT）以及组织学评分显著降低。提取物的肝保护作用可能是由于抑制了细胞色素P-450，该酶通常将扑热息痛转化为有毒的中间代谢产物N-乙酰-p-苯醌亚胺（NAPQI）。