Samal B, Stearns G, Crandall C, Arakawa T, Boone T
Amgen Inc., Amgen Center, Thousand Oaks, CA 91320.
Leuk Res. 1990;14(6):575-80. doi: 10.1016/0145-2126(90)90010-7.
Recombinant TNF was capable of inducing differentiation of human leukemic ML-1 cells in the monocytic pathway. Recombinant interleukin 6 did not have the activity but it could significantly increase the activity of recombinant TNF. Both of these molecules were found to play a similar role in PWM-induced conditioned medium from human lymphocytes (LCM). The differentiation inducing effect of LCM could be partially neutralized by antibody to interleukin 6. Fractionation of LCM also identified interleukin 6 as the factor that synergizes with TNF.
重组肿瘤坏死因子（TNF）能够诱导人白血病ML-1细胞沿单核细胞途径分化。重组白细胞介素6没有这种活性，但它能显著增强重组TNF的活性。在人淋巴细胞的PWM诱导条件培养基（LCM）中，发现这两种分子发挥类似作用。LCM的分化诱导作用可被抗白细胞介素6抗体部分中和。对LCM进行分级分离也确定白细胞介素6是与TNF协同作用的因子。
