单价型灭活轮状病毒疫苗能否诱导异型免疫？来自动物研究的证据。
Does a monovalent inactivated human rotavirus vaccine induce heterotypic immunity? Evidence from animal studies.
机构信息
Division of Viral Diseases; Centers for Disease Control and Prevention; Atlanta, GA USA.
出版信息
Hum Vaccin Immunother. 2013 Aug;9(8):1634-7. doi: 10.4161/hv.24958. Epub 2013 Jun 6.
Abstract
There is substantial evidence for broad cross-reactive immunity and heterotypic protection among human rotavirus strains in children with natural infection or with monovalent Rotarix vaccination. In this commentary, we addressed this same topic by testing sera of guinea pigs and gnotobiotic piglets that were intramuscularly immunized with an inactivated human rotavirus vaccine and also demonstrated a broad cross-protective immunity among human rotavirus strains. Our findings from a single human strain in animal studies bode well for a low cost and efficacious inactivated vaccine to protect children against rotavirus disease throughout the world.
摘要
大量证据表明，在自然感染或接种单价 Rotarix 疫苗的儿童中，人类轮状病毒株之间存在广泛的交叉反应性免疫和异型保护。在本评论中，我们通过测试用灭活的人类轮状病毒疫苗肌肉免疫的豚鼠和无菌仔猪的血清来解决这个相同的问题，并且还证明了人类轮状病毒株之间存在广泛的交叉保护免疫。我们在动物研究中对单一人类株的研究结果表明，这种低成本、有效的灭活疫苗有望在全球范围内保护儿童免受轮状病毒病的侵害。
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Human rotavirus vaccine Rotarix™ provides protection against diverse circulating rotavirus strains in African infants: a randomized controlled trial.人轮状病毒疫苗 Rotarix™ 可预防非洲婴儿中多种循环的轮状病毒株：一项随机对照试验。
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Sustained decline in rotavirus detections in the United States following the introduction of rotavirus vaccine in 2006.2006 年轮状病毒疫苗问世后，美国的轮状病毒检测数量持续下降。
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Decline in rotavirus hospitalizations and health care visits for childhood diarrhea following rotavirus vaccination in El Salvador.萨尔瓦多轮状病毒疫苗接种后，儿童腹泻的轮状病毒住院和医疗就诊率下降。
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