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Mysteries of development. How does fetal environment influence later health?

作者信息

Couzin-Frankel Jennifer

出版信息

Science. 2013 Jun 7;340(6137):1160-1. doi: 10.1126/science.340.6137.1160.

DOI:10.1126/science.340.6137.1160
PMID:23744922
Abstract
摘要

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Mysteries of development. How does fetal environment influence later health?发育之谜。胎儿环境如何影响后期健康?
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Quirks of fetal environment felt decades later.几十年后仍能感受到胎儿期环境的影响。
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Higher maternal dietary protein intake in late pregnancy is associated with a lower infant ponderal index at birth.妊娠晚期孕妇膳食蛋白质摄入量较高与出生时较低的婴儿 ponderal 指数相关。
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Association of fetal but not maternal P-glycoprotein C3435T polymorphism with fetal growth and birth weight, a possible risk factor for cardiovascular diseases in later life.胎儿而非母体的P-糖蛋白C3435T基因多态性与胎儿生长及出生体重相关,这可能是日后发生心血管疾病的一个风险因素。
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Altered fetal skeletal muscle nutrient metabolism following an adverse in utero environment and the modulation of later life insulin sensitivity.子宫内不良环境后胎儿骨骼肌营养代谢的改变及对后期生活胰岛素敏感性的调节。
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Concluding remarks.结束语。
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