Voice Neurocognition Laboratory, The Centre for Cognitive Neuroimaging, The Institute of Neuroscience and Psychology, University of Glasgow Glasgow, UK ; Department of Neuropsychiatry, Nippon Medical School Tokyo, Japan.
Front Hum Neurosci. 2013 May 24;7:221. doi: 10.3389/fnhum.2013.00221. eCollection 2013.
Impaired self-monitoring and abnormalities of cognitive bias have been implicated as cognitive mechanisms of hallucination; regions fundamental to these processes including inferior frontal gyrus (IFG) and superior temporal gyrus (STG) are abnormally activated in individuals that hallucinate. A recent study showed activation in IFG-STG to be modulated by auditory attractiveness, but no study has investigated whether these IFG-STG activations are impaired in schizophrenia. We aimed to clarify the cerebral function underlying the perception of auditory attractiveness in schizophrenia patients. Cerebral activation was examined in 18 schizophrenia patients and 18 controls when performing Favorability Judgment Task (FJT) and Gender Differentiation Task (GDT) for pairs of greetings using event-related functional MRI. A full-factorial analysis revealed that the main effect of task was associated with activation of left IFG and STG. The main effect of Group revealed less activation of left STG in schizophrenia compared with controls, whereas significantly greater activation in schizophrenia than in controls was revealed at the left middle frontal gyrus (MFG), right temporo-parietal junction (TPJ), right occipital lobe, and right amygdala (p < 0.05, FDR-corrected). A significant positive correlation was observed at the right TPJ and right MFG between cerebral activation under FJT minus GDT contrast and the score of hallucinatory behavior on the Positive and Negative Symptom Scale. Findings of hypo-activation in the left STG could designate brain dysfunction in accessing vocal attractiveness in schizophrenia, whereas hyper-activation in the right TPJ and MFG may reflect the process of mentalizing other person's behavior by auditory hallucination by abnormality of cognitive bias.
自我监测受损和认知偏差异常被认为是幻觉的认知机制；包括额下回 (IFG) 和颞上回 (STG) 在内的这些过程的基本区域在出现幻觉的个体中异常活跃。最近的一项研究表明，IFG-STG 的激活受到听觉吸引力的调节，但尚无研究调查这些 IFG-STG 激活是否在精神分裂症中受损。我们旨在阐明精神分裂症患者听觉吸引力感知的大脑功能。使用事件相关功能磁共振成像，对 18 名精神分裂症患者和 18 名对照者在执行问候语的喜好判断任务 (FJT) 和性别区分任务 (GDT) 时的大脑激活进行了检查。全因子分析显示，任务的主要效应与左 IFG 和 STG 的激活有关。组的主要效应显示，与对照组相比，精神分裂症患者左 STG 的激活较少，而左额中回 (MFG)、右颞顶联合区 (TPJ)、右枕叶和右杏仁核的激活则明显高于对照组 (p < 0.05， FDR 校正)。在 FJT 减去 GDT 对比下的大脑激活与阳性和阴性症状量表上的幻觉行为评分之间，在右 TPJ 和右 MFG 处观察到显著的正相关。左 STG 中的低激活发现可能指定了精神分裂症中获取声音吸引力的大脑功能障碍，而右 TPJ 和 MFG 的过度激活可能反映了通过认知偏差异常通过听觉幻觉对他人行为进行心理化的过程。
