Kozeko L E
Tsitol Genet. 2013 Mar-Apr;47(2):18-33.
The influence of geldanamycin (GDA)--an inhibitor of Hsp90 chaperones--on growth and morphogenesis of Arabidopsis thaliana seedlings was studied. It was shown that treatment of seeds Col with the inhibitor resulted in a dose-dependent increase in variability of seedling's rates of growth and phenotypes. GDA treatment of genetic polymorphic seeds of natural A. thaliana populations and UV-B irradiated seeds Col resulted in a significant rise in the amount of seedlings with morphological alterations and the amount of non-germinated seeds. The obtained data testify that Hsp90 may restrict stochastic processes, thereby participating in the plant development canalization, conceal genetic variations and maintain cell vitality.
研究了热休克蛋白90（Hsp90）伴侣抑制剂格尔德霉素（GDA）对拟南芥幼苗生长和形态发生的影响。结果表明，用该抑制剂处理Col种子会导致幼苗生长速率和表型变异性呈剂量依赖性增加。用GDA处理天然拟南芥种群的遗传多态性种子以及经UV-B照射的Col种子，会导致形态改变的幼苗数量和未发芽种子数量显著增加。所得数据证明，Hsp90可能会限制随机过程，从而参与植物发育的定向化，隐藏遗传变异并维持细胞活力。
