Kozeko L G
Tsitologiia. 2014;56(6):419-26.
The influence of geldanamycin (GA), which is a specific inhibitor of heat shock protein Hsp90 activities, on synthesis of Hsp70 and Hsp90 and thermotolerance of Arabidopsis thaliana seedlings has been studied. Incubation of seedlings with GA was shown to induce synthesis of these stress proteins under normal conditions. Treatment of seeds with the Hsp90 inhibitor resulted in the elevated constitutive levels of Hsp70 and Hsp90 in seedlings as well as increased induction of their synthesis under heat shock, at that the effect of GA increased with its concentration. These up-regulation of Hsp promoted thermotolerance of seedlings. The obtained results are considered as evidence for autoregulation of heat shock protein synthesis and regulation of plant tolerance by Hsp90.
格尔德霉素（GA）是热休克蛋白Hsp90活性的特异性抑制剂，本研究了其对拟南芥幼苗Hsp70和Hsp90合成以及耐热性的影响。结果表明，在正常条件下，用GA处理幼苗可诱导这些应激蛋白的合成。用Hsp90抑制剂处理种子导致幼苗中Hsp70和Hsp90的组成水平升高，同时在热激条件下其合成的诱导增加，且GA的作用随其浓度增加而增强。这些Hsp的上调促进了幼苗的耐热性。所得结果被视为热休克蛋白合成自动调节以及Hsp90对植物耐受性调节的证据。
