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[作为早产儿动脉导管关闭需求指标的动脉导管内径/体表面积]

[An index internal diameter ductus arteriosus/body surface area as a need for closure of duct in the preterm newborn].

作者信息

Tapia-Rombo Carlos Antonio, González-Arenas Moisés, Carpio-Hernández Juan Carlos, Santiago-Romo Jesús Enrique

机构信息

Servicio de Neonatologia, Unidad Médica de Alta Especialidad, Hospital General Dr. Gaudencio González Garza, Centro Médico Nacional La Raza, IMSS.

出版信息

Rev Invest Clin. 2013 Jan-Feb;65(1):12-23.

Abstract

OBJECTIVE

To determine a rate of internal diameter (ID), the narrowest of ductus arteriosus (DA)/body surface area (BSA) in preterm newborns (PTNB) for need for closure of DA either medically or surgically.

MATERIAL AND METHODS

Prospective (cohort), held in a Neonatology Service in February 2010 to January 2011. Inclusion criteria were PTNB from 28 to 36 weeks of gestation from 0 to 28 days after birth, which confirmed diagnosis of patent ductus arteriosus (PDA) by echocardiogram, taking the narrowest ID, who did not present heart complex congenital or other major malformations in other systems without pulmonary arterial hypertension, that had not received drug treatment with prostaglandin inhibitors to close the DA. The exclusion criteria for complications of mechanical ventilation (air leaks, atelectasis, etc.) before measurements. BSA was determined based on their weight and height. There were two comparison groups during its evolution, those who finally merited either closure medical or surgical closure or was indicated but the poor conditions of the patient by the same PDA mainly, the procedure was not carried out (Group A) and Group B, those that are not operated or not medically closed DA not being hemodynamically significant [corrected]. Statistical analysis was performed using descriptive statistics and inferential. Significance levels were set at p < 0.05.

RESULTS

The study population consisted of 32 patients who were divided into two groups: group A of 13 patients and group B with 19 patients. The study population characteristics between the two groups showed significant difference only in the Apgar Score for the Group B. In multivariate analysis found statistically significant as need for closure of DA only a index ID DA/ BSA when it was > 14.

CONCLUSIONS

It is important to take into account a number of known ways to assess whether the DA is hemodynamically significant and therefore should be closed medically or surgically and according to this study, a parameter to requiring its closure is an index ID DA/BSA with a value > 14.

摘要

目的

确定早产新生儿(PTNB)动脉导管(DA)内径(ID)最窄处与体表面积(BSA)的比值,以判断是否需要进行药物或手术关闭动脉导管。

材料与方法

前瞻性队列研究,于2010年2月至2011年1月在新生儿科进行。纳入标准为孕28至36周的早产新生儿,出生后0至28天,经超声心动图确诊为动脉导管未闭(PDA),取最窄内径,无心脏复杂先天性畸形或其他系统重大畸形且无肺动脉高压,未接受过前列腺素抑制剂药物治疗以关闭动脉导管。测量前排除机械通气并发症(气胸、肺不张等)。根据体重和身高确定体表面积。在其病程中有两个比较组,一组是最终需要药物或手术关闭动脉导管的,或因相同的动脉导管未闭但患者情况较差而未进行该操作的(A组);另一组是未进行手术或药物关闭动脉导管且血流动力学无显著意义的(B组)。采用描述性统计和推断性统计进行分析。显著性水平设定为p < 0.05。

结果

研究人群包括32例患者,分为两组:A组13例患者,B组19例患者。两组间研究人群特征仅在B组的阿氏评分上有显著差异。多因素分析发现,仅当动脉导管内径/体表面积指数> 14时,动脉导管关闭的需求在统计学上具有显著意义。

结论

重要的是要考虑多种已知方法来评估动脉导管是否具有血流动力学意义,从而决定是否应进行药物或手术关闭。根据本研究,一个需要关闭动脉导管的参数是动脉导管内径/体表面积指数,其值> 14。

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