Milas-Ahić Jasminka, Prus Visnja, Visević Roberta
Klinicki odjel za reumatologiju, alergologiju i klinicku imunologiju, Klinika za untarnje bolesti, Klinicki bolnicki centar Osijek, Josipa Huttlera 4, 31000 Osijek.
Reumatizam. 2012;59(2):89-92.
Hyperuricemia is rather often metabolic disorder in general population. It is multifactorial disorder influenced by purine rich diet, alcohol consumption, diuretics use and renal deterioration. In the presence of local urate superasturation and lower solubility, monosodium crystals are deposited in joints, kidneys and soft tissue leading to clinical manifestations, such as gout, tophaceus deposits, nephrolithiasis and uric nephropathy. Major advances in understanding the pathogenesis of hyperuricemia and gout have been made recently, including genetic studies of urate transporters in kidneys as well as innate immune inflammatory responses and cytokine production which will be discussed thoroughly in this paper.
高尿酸血症在普通人群中相当常见，是一种代谢紊乱疾病。它是一种多因素疾病，受富含嘌呤的饮食、饮酒、利尿剂使用和肾脏功能恶化影响。在局部尿酸过饱和且溶解度较低的情况下，尿酸钠晶体沉积在关节、肾脏和软组织中，导致痛风、痛风石沉积、肾结石和尿酸肾病等临床表现。最近在理解高尿酸血症和痛风的发病机制方面取得了重大进展，包括对肾脏尿酸转运体的遗传学研究以及先天性免疫炎症反应和细胞因子产生，本文将对此进行深入讨论。
