Department of Cardiovascular Medicine, Wakayama Medical University, Japan.
Curr Top Med Chem. 2013;13(13):1589-95. doi: 10.2174/15680266113139990107.
Peripheral arterial disease (PAD) is due to diffuse atherosclerosis. The pathological process is characterized mainly by the aberrant proliferation of vascular smooth muscle cells and the formation of neointimal lesions. MicroRNAs (miRNAs) are highly conserved non-coding small RNA molecules that regulate a large fraction of the genome by binding to complementary mRNA sequences, resulting in post-transcriptional gene silencing. Recent evidence has demonstrated that specific miRNAs are involved in the pathological development of PAD. In this review, the roles of specific miRNAs in PAD are summarized.
外周动脉疾病（PAD）是由于弥漫性动脉粥样硬化引起的。其病理过程主要表现为血管平滑肌细胞的异常增殖和新生内膜病变的形成。微小 RNA（miRNA）是高度保守的非编码小分子 RNA 分子，通过与互补的 mRNA 序列结合，在转录后水平上沉默基因，从而调控基因组的很大一部分。最近的证据表明，特定的 miRNAs 参与了 PAD 的病理发展。本综述总结了特定 miRNAs 在 PAD 中的作用。
