Department of Biology, Baylor University, Waco, TX, USA.
Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
Ther Adv Cardiovasc Dis. 2022 Jan-Dec;16:17539447221096940. doi: 10.1177/17539447221096940.
Peripheral artery disease (PAD) is a disease of atherosclerosis in the lower extremities. PAD carries a massive burden worldwide, while diagnosis and treatment options are often lacking. One of the key points of research in recent years is the involvement of microRNAs (miRNAs), which are short 20-25 nucleotide single-stranded RNAs that can act as negative regulators of post-transcriptional gene expression. Many of these miRNAs have been discovered to be misregulated in PAD patients, suggesting a potential utility as biomarkers for PAD diagnosis. miRNAs have also been shown to play an important role in many different pathophysiological aspects involved in the initiation and progression of the disease including angiogenesis, hypoxia, inflammation, as well as other cellular functions like cell proliferation and migration. The research on miRNAs in PAD has the potential to lead to a whole new class of diagnostic tools and treatments.
外周动脉疾病（PAD）是下肢动脉粥样硬化疾病。PAD 在全球造成了巨大的负担，而诊断和治疗选择往往缺乏。近年来研究的一个关键点是 microRNAs（miRNAs）的参与，miRNAs 是 20-25 个核苷酸的短单链 RNA，可以作为转录后基因表达的负调节剂。许多 miRNA 已被发现在外周动脉疾病患者中失调，这表明它们可能作为 PAD 诊断的生物标志物具有潜在的应用价值。miRNAs 在疾病发生和发展涉及的许多不同病理生理方面也发挥着重要作用，包括血管生成、缺氧、炎症以及细胞增殖和迁移等其他细胞功能。在外周动脉疾病中对 miRNAs 的研究有可能带来全新的一类诊断工具和治疗方法。
