1st Department of Cardiology, 'Hippokration' Hospital, University of Athens, Medical School, Athens, Greece.
1st Department of Cardiology, 'Hippokration' Hospital, University of Athens, Medical School, Athens, Greece.
Curr Opin Pharmacol. 2018 Apr;39:105-112. doi: 10.1016/j.coph.2018.04.001. Epub 2018 Apr 18.
Peripheral artery disease (PAD) is a vascular problem of diffuse atherosclerosis and is a major cause of cardiovascular morbidity and mortality. Many studies have tried to gain insight into the molecular mechanisms involved in PAD. Lately, highly stable circulating small noncoding RNAs, microRNAs (miRNAs), seem to have disease-specific expression. Thus, miRNAs are emerging as new measurable diagnostic biomarkers and a start point for individualized treatment. To date, the association of miRNA regulation in angiogenesis and maintenance of vascular integrity in PAD has attracted little interest. In this review, we will provide an overview of studies regarding the roles of specific miRNAs in PAD and their potential to act as a minimally invasive tool for diagnosis and risk stratification.
外周动脉疾病 (PAD) 是弥漫性动脉粥样硬化的血管问题，是心血管发病率和死亡率的主要原因。许多研究试图深入了解 PAD 中涉及的分子机制。最近，高度稳定的循环小非编码 RNA（miRNA）似乎具有特定于疾病的表达。因此，miRNA 作为新的可测量诊断生物标志物和个体化治疗的起点而出现。迄今为止，miRNA 在 PAD 中的血管生成和血管完整性维持中的调节作用的关联几乎没有引起关注。在这篇综述中，我们将概述关于特定 miRNA 在 PAD 中的作用及其作为诊断和风险分层的微创工具的潜力的研究。
