Juretić M, Cerović R, Belušić-Gobić M, Brekalo Pršo I, Kqiku L, Špalj S, Pezelj-Ribarić S
Department of Maxillofacial and Oral Surgery, School of Dentistry, Medical Faculty, University of Rijeka, Clinical Hospital Centre Rijeka, Croatia.
Folia Biol (Praha). 2013;59(2):99-102.
The aim of this study was to determine the salivary concentrations of tumour necrosis factor α (TNF-α) and interleukin 6 (IL-6) in patients with premalignant and malignant lesions. The study involved 57 patients who were examined between 2008 and 2010 at the Department of Oral Medicine and Department of Oral and Maxillofacial Surgery of the Medical Faculty, University of Rijeka, Croatia. They were divided into three groups: 19 patients with oral premalignant lesions, 19 with oral squamous cell carcinoma and 19 healthy control volunteers. Whole saliva was collected and investigated for the presence of TNF-α and IL-6 by enzyme immunoassay at the Department of Dentistry and Maxillofacial Surgery, Medical Faculty, University of Graz, Austria. All groups had statistically significant differences in values of TNF-α and IL-6 (P < 0.001). The results suggest that these proinflammatory cytokines are elevated in the saliva of patients with oral squamous cell carcinoma and oral premalignant lesions as compared to controls, which may have diagnostic and/or prognostic significance.
本研究的目的是测定癌前病变和恶性病变患者唾液中肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的浓度。该研究纳入了57例患者，他们于2008年至2010年期间在克罗地亚里耶卡大学医学院口腔医学系和口腔颌面外科接受检查。他们被分为三组：19例口腔癌前病变患者、19例口腔鳞状细胞癌患者和19名健康对照志愿者。在奥地利格拉茨大学医学院牙科学与颌面外科收集全唾液，并通过酶免疫测定法检测TNF-α和IL-6的存在情况。所有组在TNF-α和IL-6值上均存在统计学显著差异（P < 0.001）。结果表明，与对照组相比，口腔鳞状细胞癌和口腔癌前病变患者唾液中的这些促炎细胞因子升高，这可能具有诊断和/或预后意义。
